Anti-CD74 (clone 005 (A))-mc-MMAF ADC (CAT#: ADC-065CL)

This ADC product is composed of an anti-CD74 antibody (clone 005 (A)) conjugated via mc linker to MMAF(005-mcMMAF). It has demonstrated a response in Daudi-luc tumors treatment by a MOA (Mechanism of Action) as microtubule inhibitor.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • CD74 HuMab Antibody 005 (A)
  • Clone
  • 005 (A)
  • Linker
  • Mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • MMAF (Monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Alternative Names
  • CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);

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See other products for "Clone 005 (A)"

See other products for "CD74"

Single-domain Antibody

CAT Product Name Application Type
NAB-466-VHH Recombinant Anti-Human CD74 VHH Single Domain Antibody FUNC, FA, IP, ChiP Llama VHH
TAB-0004CL-VHH Anti-Human CD74 VHH Single Domain Antibody (NbhCD74n49 (Nb_49)) ELISA, FC, Internalization, Inhib, FuncS VHH
TAB-0005CL-VHH Anti-Human CD74 VHH Single Domain Antibody (NbhCD74n95 (Nb_95)) ELISA, FC, Internalization, Inhib, FuncS VHH
TAB-0006CL-VHH Anti-Human CD74 VHH Single Domain Antibody (Nb_03) ELISA, FC, Internalization, Inhib, FuncS VHH
TAB-0007CL-VHH Anti-Human CD74 VHH Single Domain Antibody (Nb_04) ELISA, FC, Internalization, Inhib, FuncS VHH

Blocking Antibody

CAT Product Name Application Type
NEUT-408CQ Mouse Anti-CD74 Recombinant Antibody (clone LN2) FC, IHC-Fr, IHC-P, ICC, IP, WB, Block Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0579 Hi-Affi™ Rabbit Anti-CD74 Recombinant Antibody (clone DS579AB) ICC, IHC-P, IP, WB Rabbit IgG

scFv Fragment Antibody

Fab Fragment Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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