The tenth fibronectin type III domain (10Fn3) that bound Abelson (Abl) kinase SH2 domain was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=7 nM) for Abelson (Abl) kinase SH2 domain as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1-VHH | Recombinant Anti-human ABL1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0964MZ | Mouse Anti-ABL1 Recombinant Antibody (clone TQN439) | IHC-P | Mouse IgG1 |
ZG-0356F | Mouse Anti-ABL1 Recombinant Antibody (ZG-0356F) | WB, ELISA | Mouse IgG |
VS3-XY13 | Mouse Anti-ABL1 Recombinant Antibody (clone 7B11D6) | ELISA, WB | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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