10-FnIII scaffold protein anti-Human Abelson (Abl) kinase SH2 domain (CAT#: SFN-L001)

The tenth fibronectin type III domain (10Fn3) that bound Abelson (Abl) kinase SH2 domain was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=7 nM) for Abelson (Abl) kinase SH2 domain as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • Fibronectin
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2 Loops
  • Target
  • Abelson (Abl) kinase SH2 domain
  • Species Reactivity
  • Human
  • Expression Host
  • BL21 (DE3) cells
  • Affinity Constant
  • 7 nM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • Fibronectin; 10-FnIII; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl

Related Resources

  • Related Signaling Pathways

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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