10-FnIII scaffold protein anti-Human Fibroblast growth factor (FGF) receptor (CAT#: SFN-L033)

The tenth fibronectin type III domain (10Fn3) that bound fibroblast growth factor (FGF) receptor was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=3 μM) for fibroblast growth factor (FGF) receptor as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • neuronal cell adhesion
    molecule L1
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2–3 Loops
  • Target
  • Fibroblast growth factor (FGF) receptor
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 3 μM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • neuronal cell adhesion molecule L1; 10-FnIII; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM

Related Resources

  • Related Diseases

Downloads

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Intrabody

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IAB-B026(A) Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] IF, FC, FuncS scFv-(D-Arg)9
IAB-B026(G) Recombinant Anti-human FGFR2 Intrabody [+36 GFP] WB, ICC, FuncS scFv-(+36GFP)
IAB-B026(T) Recombinant Anti-human FGFR2 Intrabody [Tat] ICC, Neut, FuncS scFv-Tat

Rat Antibody

CAT Product Name Application Type
TAB-284CL Anti-Human FGFR2 Recombinant Antibody (BAY 1179470) IF, WB Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1298 Hi-Affi™ Rabbit Anti-FGFR2 Recombinant Antibody (clone DS1298AB) WB, IP Rabbit IgG

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