10-FnIII scaffold protein anti-Human IL-23 (CAT#: SFN-L010)

The tenth fibronectin type III domain (10Fn3) that bound IL-23 was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.26 nM) for IL-23 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


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Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • Fibronectin
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2–3 Loops
  • Target
  • IL-23
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 0.26 nM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • Fibronectin; 10-FnIII; IL23; IL-23

Related Resources

  • Related Diseases

Downloads

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See other products for "IL23"

Human Antibody

CAT Product Name Application Type
TAB-419CL Human Anti-IL23 Recombinant Antibody (TAB-419CL) Inhib, FuncS Human IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-402CL Afuco™ Anti-IL23 Recombinant Antibody (AFC-402CL), ADCC Enhanced ELISA, WB Human IgG1

Neutralizing Antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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