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10-FnIII anti-IL-23 (SFN-L010)

The tenth fibronectin type III domain (10Fn3) that bound IL-23 was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.26 nM) for IL-23 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
10-FnIII
Origin
Fibronectin
Core Structure
β-sandwich of 7 β-strands
Variable Regions
2–3 Loops
Target
IL-23
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
0.26 nM
Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
Alternative Names
Fibronectin; 10-FnIII; IL23; IL-23

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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