10-FnIII scaffold protein anti-Human Tenascin (CAT#: SFN-L024)
The tenth fibronectin type III domain (10Fn3) that bound Tenascin was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities for Tenascin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Figure 2 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Figure 3 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enhanced (BJ hTERT+, hTEC/SVTERT24-B, U-138 MG, U-251 MG, U-87 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- Tenascin
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fibronectin; 10-FnIII; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
- Gene ID
- 3371
- UniProt ID
- P24821
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-587CT | Human Anti-TNC Recombinant Antibody (TAB-587CT) | ELISA, FC | Human lgG4 |
| TAB-588CT | Human Anti-TNC Recombinant Antibody (TAB-588CT) | ELISA, FC | Human lgG4 |
| TAB-589CT | Human Anti-TNC Recombinant Antibody (TAB-589CT) | ELISA, FC | Human lgG4 |
| TAB-590CT | Human Anti-TNC Recombinant Antibody (TAB-590CT) | ELISA, FC | Human lgG4 |
| TAB-591CT | Anti-Human Tenascin C Recombinant Antibody (2B10) | ELISA, IF | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2007CT | Recombinant Mouse anti-Human TNC Monoclonal antibody (C764N) | IHC-Fr, IHC-P | |
| HPAB-0441-YC | Mouse Anti-TNC Recombinant Antibody (clone ST2146) | ELISA, WB, FC, FuncS | Mouse IgG2b, κ |
| HPAB-0443-YC | Human Anti-TNC Recombinant Antibody (HPAB-0443-YC) | ELISA, IHC | Human IgG |
| HPAB-0444-YC | Human Anti-TNC Recombinant Antibody (HPAB-0444-YC) | ELISA, IHC | Human IgG |
| HPAB-0445-YC | Human Anti-TNC Recombinant Antibody (HPAB-0445-YC) | ELISA, IHC | Human IgG |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0810MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| BRD-0910MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2050CQ | Rat Anti-TNC Recombinant Antibody (clone CBL402) | WB, ICC, Neut | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3601 | Rabbit Anti-TNC Recombinant Antibody (clone DS3601AB) | WB, IHC, ICC | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2108 | PE-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM | |
| MHC-LC2109 | APC-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-S(P) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-0443-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0443-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0444-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0444-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0320CQ-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0320CQ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-M0678-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-M0678-YC-S(P)) | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-F(E) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| HPAB-0443-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0443-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0444-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0444-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0445-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0445-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-AP203-YC-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-AP203-YC-F(E)) | ELISA, FuncS | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-877 | Afuco™ Anti-TNC ADCC Recombinant Antibody (Tenatumomab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0083-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NJT3) | ELISA, IF | Camelid VHH |
| NBD-0084-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NJT4) | ELISA, IF, In vivo imaging | Camelid VHH |
| NBD-0085-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NJT6) | ELISA, IF, In vivo imaging | Camelid VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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