Anti-FcRL5 (10A8)-SPDB-DM4 ADC (CAT#: ADC-117LCT)
This ADC product is composed of an anti-FcRL5 antibody (clone 10A8) conjuagated via a SPDB linker to DM4 (10A8-SPDB-DM4). It has demonstrated a response in multiple myeloma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Group enriched (U-266/70, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143297-FCRL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143297-FCRL5
Specifications
- Clone
- 10A8
- Linker
- SPDB
- Linker Class/Description
- Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
- Alternative Names
- FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);
- Gene ID
- 83416
- UniProt ID
- Q96RD9
Downloads
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See other products for "Clone 10A8"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2390z | Mouse Anti-FCRL5 Recombinant Antibody (MOB-2390z) | FC, CyTOF | Mouse IgG1 |
| HPAB-0016CQ | Human Anti-FCRL5 Recombinant Antibody (HPAB-0016CQ) | ELISA, WB, RIA | Human IgG1, κ |
| HPAB-0017CQ | Human Anti-FCRL5 Recombinant Antibody (HPAB-0017CQ) | ELISA, WB, RIA | Human IgG1, λ |
| HPAB-0018CQ | Human Anti-FCRL5 Recombinant Antibody (HPAB-0018CQ) | RIA, ELISA | Humanized IgG1, κ |
| MOB-056CQ | Mouse Anti-FCRL5 Recombinant Antibody (MOB-056CQ) | ELISA, FC, FuncS | Mouse IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2390z-S(P) | Recombinant Anti-Human FCRL5 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-0016CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-0016CQ-S(P)) | ELISA, WB, RIA | Human scFv |
| HPAB-0017CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-0017CQ-S(P)) | ELISA, WB, RIA | Human scFv |
| HPAB-0018CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-0018CQ-S(P)) | RIA, ELISA | Humanized scFv |
| HPAB-1807LY-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-1807LY-S(P)) | ELISA, FC | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0590CL | Mouse Anti-FCRL5 Recombinant Antibody (TAB-0590CL) | FC, WB, ELISA | Mouse IgG2a |
| TAB-0591CL | Mouse Anti-FCRL5 Recombinant Antibody (TAB-0591CL) | FC, IF, WB, ELISA | Mouse IgG1 |
| TAB-0590CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0590CL-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-0591CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0591CL-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-0592CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0592CL-S(P)) | ELISA, FC, WB | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-0016CQ-F(E)) | ELISA, WB, RIA | Human Fab |
| HPAB-0017CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-0017CQ-F(E)) | ELISA, WB, RIA | Human Fab |
| HPAB-0018CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-0018CQ-F(E)) | RIA, ELISA | Humanized Fab |
| HPAB-0180CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody (clone 9D12); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0181CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody (clone 8A1); Fab Fragment | ELISA, FC | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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