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Anti-CD72 (clone 10D6.8.1)-SPP-DM1 ADC (CAT#: ADC-177LZY)

This ADC product is composed of an anti-CD72 antibody (clone 10D681 ) conjugated via SPP linker to DM1 (10D681-SPP-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44658/1373_H2_4_selected.jpg
Normal Tissue
Figure 2 Spleen
Figure 2 Spleen
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/ihc_selected.jpg
Figure 3 Bone marrow
Figure 3 Bone marrow
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_B_5_4.jpg
Figure 4 High expression in lymph node
Figure 4 High expression in lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137101-CD72

Specifications

  • Antibody Overview
  • Mouse Anti-CD72 IgG1,10D6.8.1
  • Clone
  • 10D681
  • Antibody Isotype
  • IgG1
  • Linker
  • SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Linker Class/Description
  • Class: Chemically cleavable Linker-Disulfide Linker
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells, where it appears to mediate aspects of B-cell-T-cell interaction. It is a ligand for CD5.
  • Alternative Names
  • CD72; CD72 molecule; LYB2; CD72b; B-cell differentiation antigen CD72; lyb-2; CD72 antigen;

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Recombinant Antibody

CAT Product Name Application Type
MOB-1916z Mouse Anti-CD72 Recombinant Antibody (clone 24B5) WB, FC, IHC, IP Mouse IgG2a
MOB-1640MZ Recombinant Mouse Anti-Human CD72 Antibody (clone 4G4) FC, IP Mouse antibody
HPAB-0062CQ Human Anti-CD72 Recombinant Antibody (clone sc02-004) IHC Human IgG1, κ
HPAB-2053-FY Human Anti-CD72 Recombinant Antibody (clone II-2) FC Human IgG1
FAMAB-1080CQ Human Anti-CD72 Recombinant Antibody (clone BU40) WB, FC, Apop Human IgG1

Immunotoxin

CAT Product Name Application Type
AGTO-G083P Anti-CD72 immunotoxin J3-109 (IgG)-PAP Cytotoxicity assay, Function study

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0578 Hi-Affi™ Rabbit Anti-CD72 Recombinant Antibody (clone DS578AB) ICC, WB Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0062CQ-S(P) Human Anti-CD72 Recombinant Antibody (clone sc02-004); scFv Fragment IHC Human scFv
HPAB-0063CQ-S(P) Human Anti-CD72 Recombinant Antibody (clone sc02-025); scFv Fragment IHC Human scFv
HPAB-2053-FY-S(P) Human Anti-CD72 Recombinant Antibody (clone II-2); scFv Fragment FC Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0062CQ-F(E) Human Anti-CD72 Recombinant Antibody (clone sc02-004); Fab Fragment IHC Human Fab
HPAB-0063CQ-F(E) Human Anti-CD72 Recombinant Antibody (clone sc02-025); Fab fragment IHC Human Fab
HPAB-2053-FY-F(E) Human Anti-CD72 Recombinant Antibody (clone II-2); Fab Fragment FC Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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