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Anti-NTB-A (clone 11A1)-vc-MMAE ADC (CAT#: ADC-360CL)

This ADC product is composed of an anti-NTB-A antibody (clone 11A1) conjugated via vc linker to MMAE(11A1-vc-MMAE). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEL
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51363/1770_E2_2_selected.jpg
Figure 2 IHC staining of human tonsil
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows moderate positivity in germinal center and non-germinal center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51363/119554_A_6_8_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51363/1886_H5_1_blue_red_green.jpg
Normal Tissue
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51903/119543_A_8_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51363/119554_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51903/119543_A_4_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51363/119554_A_7_8.jpg
Figure 8 Tonsil
Figure 8 Tonsil
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51363/119554_A_6_8.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (Daudi, U-698)
Figure 9 RNA cell line category: Group enriched (Daudi, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162739-SLAMF6

Specifications

  • Antibody Overview
  • Murine Anti-NTB-A monoclonal Antibody 11A1
  • Clone
  • 11A1
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
  • Alternative Names
  • SLAMF6; SLAM family member 6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; NTBA receptor; NK-T-B-antigen; activating NK receptor; natural killer-, T-and B-cell antigen;

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Single-domain Antibody

CAT Product Name Application Type
NAB-2322-sdAb Recombinant Anti-Human SLAMF6 VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH

Recombinant Antibody

CAT Product Name Application Type
MOB-2889z Mouse Anti-SLAMF6 Recombinant Antibody (clone 34H9) WB, FC Mouse IgG2a
MOB-0073CT Recombinant Mouse anti-Human SLAMF6 Monoclonal antibody (OU-8) FC, IP
FN-191CQ Recombinant Mouse Anti-SLAMF6 Antibody (13G3-19D) FC, FuncS, IP, WB, Block Mouse IgG2a, κ
MOB-067YJL Mouse Anti-SLAMF6 Recombinant Antibody (clone CBS211) FC, ELISA, Neut Mouse IgG2a
VS-0224-XY92 Mouse Anti-Mouse Slamf6 Recombinant Antibody (VS-0224-XY92) FC Mouse IgG2a

Chimeric Antibody

CAT Product Name Application Type
TAB-605MZ Human Anti-SLAMF6 Recombinant Antibody (TAB-605MZ) Cyt, FuncS Chimeric antibody (mouse/human)
TAB-605MZ-S(P) Mouse Anti-SLAMF6 Recombinant Antibody; scFv Fragment (TAB-605MZ-S(P)) FC, WB Mouse scFv
TAB-605MZ-F(E) Human Anti-SLAMF6 Recombinant Antibody; Fab Fragment (TAB-605MZ-F(E)) FC, WB Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-601MZ-S(P) Mouse Anti-SLAMF6 Recombinant Antibody; scFv Fragment (TAB-601MZ-S(P)) Internalization assay, FC Mouse scFv
TAB-602MZ-S(P) Mouse Anti-SLAMF6 Recombinant Antibody; scFv Fragment (TAB-602MZ-S(P)) Internalization assay, FC Mouse scFv
TAB-603MZ-S(P) Mouse Anti-SLAMF6 Recombinant Antibody; scFv Fragment (TAB-603MZ-S(P)) FC, WB Mouse scFv
TAB-604MZ-S(P) Mouse Anti-SLAMF6 Recombinant Antibody; scFv Fragment (TAB-604MZ-S(P)) FC, WB Mouse scFv
TAB-601MZ-F(E) Mouse Anti-SLAMF6 Recombinant Antibody; Fab Fragment (TAB-601MZ-F(E)) Internalization assay, FC Mouse Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-1973CQ Recombinant Mouse Anti-SLAMF6 Antibody (NT-7) FC, BL IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3278 Hi-Affi™ Recombinant Rabbit Anti-Slamf6 Monoclonal Antibody (DS3278AB) WB, IP IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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