Anti-FGFR2 (clone 12433)-sulfo-SMCC-DM1 ADC (CAT#: ADC-076CL)

This ADC product is composed of an anti-FGFR2 antibody (clone 12433) conjugated via sulfo-SMCC linker to DM1(12433-MCC-DMl). It has demonstrated a response in FGFR2 positive cancer, resistant cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-FGFR2 Antibody, Antibody 12433
  • Clone
  • 12433
  • Linker
  • sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
  • Alternative Names
  • FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14;

Related Resources

  • Related Diseases

Downloads

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See other products for "FGFR2"

Intrabody

CAT Product Name Application Type
IAB-B026(A) Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] IF, FC, FuncS scFv-(D-Arg)9
IAB-B026(G) Recombinant Anti-human FGFR2 Intrabody [+36 GFP] WB, ICC, FuncS scFv-(+36GFP)
IAB-B026(T) Recombinant Anti-human FGFR2 Intrabody [Tat] ICC, Neut, FuncS scFv-Tat

Rat Antibody

CAT Product Name Application Type
TAB-284CL Anti-Human FGFR2 Recombinant Antibody (BAY 1179470) IF, WB Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1298 Hi-Affi™ Rabbit Anti-FGFR2 Recombinant Antibody (clone DS1298AB) WB, IP Rabbit IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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