Anti-EphA2 receptor (1C1)-vcMMAE ADC (CAT#: ADC-113LCT)
This ADC product is composed of an anti-EphA2 receptor antibody (clone 1C1) conjuagated via a Mc linker to MMAF (1C1-vcMMAE). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
Specifications
- Antibody Overview
- Fully Human monoclonal Antibody (1C1) Anti-EphA2 receptor
- Clone
- 1C1
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
- Alternative Names
- EPHA2; EPH receptor A2; ECK; CTPA; ARCC2; CTPP1; CTRCT6; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase;
- Gene ID
- 1969
- UniProt ID
- A0A024QZA8
Downloads
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See other products for "Clone 1C1"
See other products for "EPHA2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1460z | Mouse Anti-EPHA2 Recombinant Antibody (clone 31G12) | WB, ELISA, ICC, IF | Mouse IgG2b, κ |
| HPAB-0450-CN | Mouse Anti-EPHA2 Recombinant Antibody (HPAB-0450-CN) | ELISA, WB, FC, IP | Mouse IgG2a |
| HPAB-0452-CN | Human Anti-EPHA2 Recombinant Antibody (HPAB-0452-CN) | ELISA, WB, FC, IP | Humanized IgG1 |
| HPAB-0453-CN | Human Anti-EPHA2 Recombinant Antibody (clone 4H5) | ELISA, FC, IF | Humanized IgG |
| HPAB-0454-CN | Human Anti-EPHA2 Recombinant Antibody (clone 2A4) | ELISA, FC, IF, Agonist | Humanized IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-381MZ | Anti-Human EPHA2 Recombinant Antibody (LUCA40) | FC | |
| TAB-382MZ | Anti-Human EPHA2 Recombinant Antibody (SPL1) | IHC, WB, sELISA | |
| TAB-383MZ | Anti-Human EPHA2 Recombinant Antibody (SG5 ) | IHC, WB, sELISA | |
| TAB-384MZ | Mouse Anti-EPHA2 Recombinant Antibody (TAB-384MZ) | ELISA | Mouse IgG |
| TAB-380MZ-S(P) | Mouse Anti-EPHA2 Recombinant Antibody; scFv Fragment (TAB-380MZ-S(P)) | IHC, WB, sELISA | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-385MZ | Human Anti-EPHA2 Recombinant Antibody (TAB-385MZ) | ELISA | Humanized IgG |
| TAB-385MZ-S(P) | Human Anti-EPHA2 Recombinant Antibody; scFv Fragment (TAB-385MZ-S(P)) | ELISA | Humanized scFv |
| TAB-385MZ-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (TAB-385MZ-F(E)) | ELISA | Humanized Fab |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC145 | PE-A*02:01/Human EphA2 (TLADFDPRV) MHC Tetramer | FCM | |
| MHC-LC146 | APC-A*02:01/Human EphA2 (TLADFDPRV) MHC Tetramer | FCM | |
| MHC-YF418 | A*02:01/Human EPHA2 (VLAGVGFFI) MHC Pentamer | FCM |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1164 | Hi-Affi™ Rabbit Anti-EPHA2 Recombinant Antibody (clone DS1164AB) | WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0450-CN-F(E) | Mouse Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0450-CN-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| HPAB-0452-CN-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0452-CN-F(E)) | ELISA, WB, FC, IP | Humanized Fab |
| HPAB-0453-CN-F(E) | Human Anti-EPHA2 Recombinant Antibody (clone 4H5); Fab Fragment | ELISA, FC, IF | Humanized Fab |
| HPAB-0454-CN-F(E) | Human Anti-EPHA2 Recombinant Antibody (clone 2A4); Fab Fragment | ELISA, FC, IF, Agonist | Humanized Fab |
| HPAB-0455-CN-F(E) | Mouse Anti-EPHA2 Recombinant Antibody (clone EA2); Fab Fragment | ELISA, FC, IF | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0164CQ-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone G5); scFv Fragment | ELISA, IF, FC, FuncS, Inter | Humanized scFv |
| HPAB-0165CQ-S(P) | Mouse Anti-EPHA2 Recombinant Antibody (clone B233); scFv Fragment | ELISA, IF, FC, FuncS | Mouse scFv |
| HPAB-0166CQ-S(P) | Mouse Anti-EPHA2 Recombinant Antibody (clone B208); scFv Fragment | ELISA, IF, FC, FuncS | Mouse scFv |
| HPAB-0167CQ-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone 3F2); scFv Fragment | ELISA, IF, FC, FuncS | Human scFv |
| HPAB-0168CQ-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone 1F12); scFv Fragment | ELISA, IF, FC, FuncS, Activ | Human scFv |
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