Anti-cKIT (clone 9P3)-SPDB-DM4 ADC (CAT#: ADC-102CL)
This ADC product is composed of an anti-cKIT antibody (clone 9P3) conjugated via SPDB linker to DM4(9P3-SPDB-DM4). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
Figure 2 High expression in breast
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
Figure 3 High expression in lung.
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
Figure 4 Skin
(Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
(Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
Figure 5 RNA cell line category: Group enriched (HEL, HMC-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
Specifications
- Antibody Overview
- Anti-cKIT Antibody 9P3
- Clone
- 9P3
- Linker
- SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Linker Class/Description
- Class: Chemically cleavable linkers-Disulfide Linkers
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117; mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein;
- Gene ID
- 3815
- UniProt ID
- A0A024RDA0
Downloads
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See other products for "Clone 9P3"
See other products for "KIT"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1436z | Mouse Anti-KIT Recombinant Antibody (clone 21G5) | ELISA, IHC, WB | Mouse IgG |
| PABL-642 | Mouse Anti-KIT Recombinant Antibody (clone 79D) | WB, FuncS | Mouse IgG |
| MOB-0966MZ | Recombinant Mouse Anti-Human KIT Antibody (clone C-L26) | ELISA | Mouse antibody |
| FAMAB-0024-CN | Mouse Anti-KIT Recombinant Antibody (clone Kit2C75) | FC | Mouse IgG |
| HPAB-1952-FY | Mouse Anti-KIT Recombinant Antibody (HPAB-1952-FY) | ELISA, Inhib | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-470CL | Human Anti-KIT Recombinant Antibody (TAB-470CL) | ELISA, WB | Human IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-450CL | Afuco™ Anti-KIT Recombinant Antibody (AFC-450CL), ADCC Enhanced | ELISA, WB | Humanized IgG1 |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-465LC | Human Anti-KIT Recombinant Antibody (TAB-465LC) | ELISA, SPR | Human antibody |
| TAB-466LC | Human Anti-KIT Recombinant Antibody (TAB-466LC) | ELISA, SPR | Human antibody |
| TAB-465LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-465LC-S(P)) | FC, WB, SPR, ELISA | Human scFv |
| TAB-466LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-466LC-S(P)) | FC, WB, SPR, ELISA | Human scFv |
| TAB-468LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-468LC-S(P)) | FC, WB, ELISA | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467LC | Anti-Human KIT Recombinant Antibody (SR1) | WB | |
| TAB-467LC-S(P) | Anti-Human KIT Recombinant Antibody scFv Fragment (SR1) | WB | |
| TAB-467LC-F(E) | Anti-Human KIT Recombinant Antibody Fab Fragment (SR1) | WB |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0316MZ | Chicken Anti-KIT Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1629CQ | Recombinant Mouse Anti-KIT Antibody (A3C6E2) | FC, BL | IgG1, κ |
| NEUT-1633CQ | Recombinant Rat Anti-Kit Antibody (ACK2) | FC, BL, Depletion | IgG2b, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1630CQ | Recombinant Mouse Anti-KIT Antibody (CBL788) | WB, FC, CyTOF, ELISA(Cap), Neut | IgG1 |
| NEUT-1631CQ | Recombinant Mouse Anti-KIT Antibody (14G5) | Neut, WB | IgG1 |
| NEUT-1632CQ | Recombinant Mouse Anti-KIT Antibody (12A8) | WB, IP, FC, Neut | IgG1 |
| NEUT-1634CQ | Recombinant Mouse Anti-KIT Antibody (CBL158) | Neut, WB | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1948 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (DS1948AB) | IHC-P, IHC-Fr | IgG |
| MOR-4551 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (TH61DS) | WB, IF, ICC | IgG |
| MOR-4552 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (TH62DS) | WB, IF, ICC, FC | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0024-CN-S(P) | Mouse Anti-KIT Recombinant Antibody (clone Kit2C75); scFv Fragment | FC | Mouse scFv |
| HPAB-0019-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-0019-FY-S(P)) | FC | Humanized scFv |
| HPAB-1948-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1948-FY-S(P)) | Block, ELISA, FC, IF | Humanized scFv |
| HPAB-1949-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1949-FY-S(P)) | Block, ELISA, FC, IF | Humanized scFv |
| HPAB-1950-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1950-FY-S(P)) | Block, ELISA, FC, IF | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0024-CN-F(E) | Mouse Anti-KIT Recombinant Antibody (clone Kit2C75); Fab Fragment | FC | Mouse Fab |
| HPAB-0019-FY-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-0019-FY-F(E)) | FC | Humanized Fab |
| HPAB-N0156-YC-F(E) | Mouse Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-N0156-YC-F(E)) | ELISA, Inhib, FuncS | Mouse Fab |
| HPAB-N0157-YC-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-N0157-YC-F(E)) | ELISA, Inhib, FuncS | Humanized Fab |
| HPAB-3398LY-F(E) | Human Anti-KIT Recombinant Antibody (clone 37M); Fab Fragment | ELISA, FC, WB | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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