APC-A*02:01/Human WT1 (VLDFAPPGA) MHC Tetramer (CAT#: MHC-LC196)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of WT1-derived peptide of VLDFAPPGA sequence covering 37-45 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
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Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • WT1
  • Antigen Species
  • Human
  • Peptide
  • VLDFAPPGA
  • Range
  • 37-45
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
  • Alternative Names
  • WT1; Wilms tumor 1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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