Anti-CXCR4 (A122)-pAcF-MMAF ADC (CAT#: ADC-095LCT)

This ADC product is composed of an anti-CXCR4 antibody (ulocuplumab) conjuagated via a p-acetyl phenylalanine (pAcF) linker to MMAF (A122-pAcF-MMAF). It has demonstrated a response in metastatic malignancies. treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
RNA Expression

Specifications

  • Antibody Overview
  • Fully Human IgG4 monoclonal Anti-CXCR4 Antibody
  • Clone
  • ulocuplumab
  • Antibody Isotype
  • IgG4
  • Linker
  • p-acetyl phenylalanine (pAcF)
  • Linker Class/Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAF (Monomethyl auristatin F)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;

Downloads

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Chicken IgY Antibody

CAT Product Name Application Type
BRD-0152MZ Chicken Anti-CXCR4 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-686CQ Mouse Anti-CXCR4 Recombinant Antibody (clone 44716.111) FC, ICC, IF, IHC-P, Inhib Mouse IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0889 Hi-Affi™ Rabbit Anti-CXCR4 Recombinant Antibody (clone DS889AB) WB, IHC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H72 Afuco™ Anti-CXCR4 ADCC Recombinant Antibody (Ulocuplumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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