Anti-SLITRK6 (AGS15)-mc-vc-MMAE ADC (CAT#: ADC-156LCT)

This ADC product is composed of an anti-SLITRK6 antibody (clone AGS15) conjuagated via a mc-vc linker to MMAE (AGS15-mc-vc-MMAE). It has demonstrated a response in bladder cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Human IgG2 monoclonal Antibody (AGS15)
  • Clone
  • AGS15
  • Antibody Isotype
  • IgG2
  • Linker
  • mc-VC (maleimidocaproyl-valine-citrulline)
  • Linker Class/Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]
  • Alternative Names
  • SLITRK6; SLIT and NTRK-like family, member 6; DFNMYP; SLIT and NTRK-like protein 6; 4832410J21Rik; slit and trk like gene 6;

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SLITRK6"

Recombinant Antibody

CAT Product Name Application Type
VS-0923-FY258 Recombinant Human Anti-SLITRK6 Antibody (clone Sirtratumab) ELISA, WB Human IgG2, kappa

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ADC-156LCT. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare