Products

Abciximab (TP-100CL)

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.      

Specifications
Classify
Protein therapeutics that interfere with a molecule or organism: Haemostasis and thrombosis
Therapeutic
Abciximab
Trade Name
Reopro
Function
Fab fragment of chimeric (human/mouse) mAb 7e3 that inhibits platelet aggregation by binding to the glycoprotein iib/iiia integrin receptor
Examples of Clinical Use
Adjunct to aspirin and heparin for prevention of cardiac ischaemia in patients undergoing percutaneous coronary intervention or patients about to undergo percutaneous coronary intervention with unstable angina not responding to medical therapy
References
Synonyms
7E3, 7E3 antibody, antiGPIIBIIIa, C7E3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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