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Aldesleukin (TP-046CL)

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Immunoregulation
Therapeutic
Aldesleukin (interleukin 2 (IL2), epidermal thymocyte activating factor; eTAF)
Trade Name
Proleukin
Function
Stimulates T and B cells, natural killer cells, and lymphokine-activated killer cells
Examples of Clinical Use
Metastatic renal cell cancer, melanoma
References
Synonyms
IL-2, Interleukin-2 precursor, T-cell growth factor, TCGF
UniProt
P60569
Genbank
M11144

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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