Products

Alefacept (TP-089CL)

Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.      

Specifications
Classify
Protein therapeutics that interfere with a molecule or organism: Immunoregulation
Therapeutic
Alefacept
Trade Name
Amevive
Function
Dimeric fusion protein that binds cD2 on the surface of lymphocytes and inhibits interaction with LFA3; this association is important for the activation of T lymphocytes in psoriasis
Examples of Clinical Use
Adults with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy
References
Synonyms
ASP0485

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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