Alpha-1-proteinase inhibitor (CAT#: TP-022CL)
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/927/1399_A10_5_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/927/1399_A10_5_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/927/2684_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/927/2684_B_7_5.jpg
Figure 3 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16648/40122_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16648/40122_A_8_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/927/2684_A_6_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/927/2684_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197249-SERPINA1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197249-SERPINA1
Specifications
- Classify
- Protein therapeutics replacing a protein that is deficient or abnormal: Pulmonary and gastrointestinal-tract disorders
- Therapeutic
- α-1-Proteinase inhibitor
- Trade Name
- Aralast, Prolastin
- Function
- Inhibits elastase-mediated destruction of pulmonary tissue; purified from pooled human plasma
- Examples of clinical use
- Congenital a-1-antitrypsin deficiency
References
- Synonyms
- Alpha 1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha-1-proteinase Inhibitor (human), Alpha-1-proteinase inhibitor human, Alpha-1-proteinase Inhibitor, Human, Alpha1-proteinase Inhibitor, Alpha1-proteinase inhibitor (human), alpha1-proteinase inhibitor human
- UniProt
- P01009
- Genbank
- K01396
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3947z | Mouse Anti-SERPINA1 Recombinant Antibody (clone 8F12) | WB, Dot, ELISA | Mouse IgG1 |
| HPAB-0408-YJ | Mouse Anti-SERPINA1 Recombinant Antibody (clone 3H12-2C2) | ELISA, Inhib | Mouse IgG |
| PABJ-0157 | Mouse Anti-SERPINA1 Recombinant Antibody (clone 1D9) | ELISA | Mouse IgG |
| PABJ-0203 | Mouse Anti-SERPINA1 Recombinant Antibody (clone 2H2) | IF, FuncS | Mouse IgG |
| VS3-XY1410 | Mouse Anti-SERPINA1 Recombinant Antibody (clone 2B12) | ELISA, WB | Mouse IgG1 |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0846MZ | Chicken Anti-alpha-1 Antitrypsin Polyclonal IgY | ELISA, WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3212 | Hi-Affi™ Recombinant Rabbit Anti-SERPINA1 Monoclonal Antibody (DS3212AB) | WB | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0408-YJ-S(P) | Mouse Anti-SERPINA1 Recombinant Antibody (clone 3H12-2C2); scFv Fragment | ELISA, Inhib | Mouse scFv |
| PABJ-0157-S(P) | Mouse Anti-SERPINA1 Recombinant Antibody (clone 1D9); scFv Fragment | ELISA | Mouse scFv |
| PABJ-0203-S(P) | Mouse Anti-SERPINA1 Recombinant Antibody (clone 2H2); scFv Fragment | IF, FuncS | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0408-YJ-F(E) | Mouse Anti-SERPINA1 Recombinant Antibody (clone 3H12-2C2); Fab Fragment | ELISA, Inhib | Mouse Fab |
| PABJ-0157-F(E) | Mouse Anti-SERPINA1 Recombinant Antibody (clone 1D9); Fab Fragment | ELISA | Mouse Fab |
| PABJ-0203-F(E) | Mouse Anti-SERPINA1 Recombinant Antibody (clone 2H2); Fab Fragment | IF, FuncS | Mouse Fab |
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