Anistreplase (CAT#: TP-077CL)

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.


  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Classify
  • Protein therapeutics providing a novel function or activity: Haemostasis and thrombosis
  • Therapeutic
  • Anistreplase (anisoylated plasminogen streptokinase activator complex; APsAc)
  • Trade Name
  • Eminase
  • Function
  • Converts plasminogen to plasmin; p-anisoyl group protects the catalytic centre of the plasminogen-streptokinase complex and prevents premature deactivation, thereby providing longer duration of action than streptokinase
  • Examples of clinical use
  • Thrombolysis in patients with unstable angina

References

  • Synonyms
  • t- PA, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA
  • UniProt
  • P00750
  • Genbank
  • L00153

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