Products

Anistreplase (TP-077CL)

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.      

Specifications
Classify
Protein therapeutics providing a novel function or activity: Haemostasis and thrombosis
Therapeutic
Anistreplase (anisoylated plasminogen streptokinase activator complex; APsAc)
Trade Name
Eminase
Function
Converts plasminogen to plasmin; p-anisoyl group protects the catalytic centre of the plasminogen-streptokinase complex and prevents premature deactivation, thereby providing longer duration of action than streptokinase
Examples of Clinical Use
Thrombolysis in patients with unstable angina
References
Synonyms
t- PA, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA
UniProt
P00750
Genbank
L00153

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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