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Ankyrin repeat anti-IL4 (SAR-L261)

The Ankyrin repeat that bound IL4 was isolated from the library using ribosome display techonology. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. After affinity maturation, Ankyrin repeat variants were identified having affinities (KD=9.0 pM) for IL4 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
Ankyrin repeat
Origin
Ankyrin repeat proteins
Core Structure
2α-helices, β-turn
Variable Regions
b-turn,1a-helix and loop
Target
IL4
Species Reactivity
Human
Expression Host
BL21 (DE3) cells
Affinity Constant
9.0 pM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Entrez Gene ID
3565
UniProt ID
P05112

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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