Products

Anti-ABL Intrabody [+36GFP] (IAB-B048(G))

Recombinant anti-ABL intrabody in fusion with +36GFP works within cells to bind human ABL, expressed in CHO cells. Inhibition of the BCR/ABL protein tyrosine kinase activity by the intrabody blocked BCR/ABL signal transduction pathway,reversed the effect of BCR/ABL on cell growth and apoptosis.      

Specifications
Immunogen
human ABL proto-oncogene 1, non-receptor tyrosine kinase
Host
mouse
Type
scFv-(+36GFP)
Cell Penetrating Peptide
+36 GFP
GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
Species Reactivity
human
Applications
Formats of immunological tests: Coimmunopricipation; Functional studies
Target
Alternative Names
Abelson murine leukemia viral oncogene homolog 2; Abelson related gene protein; Abelson tyrosine-protein kinase 2;
Abelson-related gene protein; ABL2; ABL2_HUMAN; ABLL; ARG
Entrez Gene ID
25

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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