Recombinant Anti-human ABL Intrabody [(D-Arg)9] (CAT#: IAB-B048(A))

Recombinant anti-ABL intrabody linked to (D-Arg)9 works within cells and specifically reacts with human ABL, expressed in CHO cells. Inhibition of the BCR/ABL protein tyrosine kinase activity by the intrabody blocked BCR/ABL signal transduction pathway,reversed the effect of BCR/ABL on cell growth and apoptosis.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human ABL proto-oncogene 1, non-receptor tyrosine kinase
  • Host Species
  • mouse
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Can be useful in applications such as: Flow Cytometry; Immunofluorescence; Functional studies

Product Property

  • Purity
  • Purity>95% by SDS-PAGE
  • Storage
  • Store at -20°C. Open under aseptic conditions.

Target

  • Alternative Names
  • Abelson murine leukemia viral oncogene homolog 2; Abelson related gene protein; Abelson tyrosine-protein kinase 2;
    Abelson-related gene protein; ABL2; ABL2_HUMAN; ABLL; ARG; Tyrosine kinase ARG; Tyrosine protein kinase ABL2; Tyrosine-protein kinase A

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ABL"

Intrabody

CAT Product Name Application Type
IAB-B048(G) Recombinant Anti-human ABL Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
IAB-B048(T) Recombinant Anti-human ABL Intrabody [Tat] ELISA, IF, Neut, FuncS scFv-Tat

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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