The anti-ADAM12 antibody target A Disintegrin And Metal loprotease12 which is highly upregulated in a variety of human cancers including breast, bladder, laryngeal and lung carcinomas.
Figure 1 Monoclonal antibodies against ADAM12 inhibit ADAM12-induced gelatin degradation.
In situ solid-phase gelatinase assay of 293-VnR cells transfected with ADAM12Dcyt and treated overnight with 4 mg/ml of mAbs against ADAM12 (6E6, 7B8 and 8F8). Dishes were stained using the ADAM12 monoclonal antibody 6E6 (red) and DAPI (blue).
Albrechtsen, R., Kveiborg, M., Stautz, D., Vikeså, J., Noer, J. B., Kotzsh, A., ... & Fröhlich, C. (2013). ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth. J Cell Sci, 126(20), 4707-4720.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0435MZ | Mouse Anti-ADAM12 Recombinant Antibody (clone 632525) | WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3948 | Hi-Affi™ Rabbit Anti-ADAM12 Recombinant Antibody (clone SI8DS) | ELISA | Rabbit IgG |
MOR-3949 | Hi-Affi™ Rabbit Anti-ADAM12 Recombinant Antibody (clone SI9DS) | WB, IP | Rabbit IgG |
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