Mouse Anti-APP Recombinant Antibody (clone 10D5) (CAT#: PABL-401)
Recombinant Mouse Antibody (10D5) is capable of binding to APP. This antibody recognizes Aβ residues 3–7.
Specific Inquiry
IF
Figure 1 Application of anti-amyloid antibody 10D5 clears amyloid-β plaques.
Amyloid-β plaque clearance occurred only in cortical tissue treated with 10D5. Amyloid protein was immunostained with fluorescent 3D6. Untreated area of cortexin animal treated with 10D5. Plaques are clearly visible (arrow). Scale bar, 50μm.
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003). Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. Journal of Neuroscience, 23(34), 10879-10883.
FuncS
Figure 2 Application of anti-amyloid antibody 10D5 clears amyloid-β plaques.
Comparison of amyloid burden measured with 3D6 antibody under different experimental conditions. The values are the means; error bars indicate SD.
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003). Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. Journal of Neuroscience, 23(34), 10879-10883.
IF
Figure 3 Amyloid-β clearance restores the morphology of neurites.
Untreated area of cortex from 10D5-treated animal, immunostained with Cy-3-SMI-32.
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003). Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. Journal of Neuroscience, 23(34), 10879-10883.
Specifications
- Immunogen
- Human amyloid beta (A4) precursor protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG2a
- Specificity
- APP
- Species Reactivity
- Human
- Clone
- 10D5
- Applications
- IF, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Immunofluorescence and Function Assay.
Target
- Alternative Names
- APP; amyloid beta (A4) precursor protein; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; amyloid beta A4 protein; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); alzheimer disease amyloid protein; cerebral vascular amyloid peptide
- Gene ID
- 351
- UniProt ID
- P05067
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-227 | Anti-Human Abeta Recombinant Antibody (Ponezumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG2 - kappa |
| TAB-253CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-253CQ-F(E)) | ELISA | Humanized Fab |
| TAB-0790CLV | Mouse Anti-APP Recombinant Antibody (TAB-0790CLV) | ELISA | Humanized IgG |
| TAB-0828CLV | Human Anti-APP Recombinant Antibody (TAB-0828CLV) | ELISA | Humanized antibody |
| TAB-0829CLV | Human Anti-APP Recombinant Antibody (TAB-0829CLV) | ELISA | Humanized antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-010 | Mouse Anti-APP Recombinant Antibody (clone 12A11); scFv Fragment | WB, IF, FuncS | Mouse scFv |
| PSBL-011 | Mouse Anti-APP Recombinant Antibody (clone 3D6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBL-012 | Human Anti-APP Recombinant Antibody (clone 9TL); scFv Fragment | WB, FuncS | Human scFv |
| PSBL-013 | Mouse Anti-APP Recombinant Antibody (clone C705); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBW-009 | Mouse Anti-APP Recombinant Antibody (clone PFA1); scFv Fragment | ELISA | Mouse scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-003 | Recombinant Anti-Human APP VHH Single Domain Antibody (G7) | WB, ELISA, FuncS | Llama VHH |
| PNBL-004 | Recombinant Anti-Human APP VHH Single Domain Antibody (PS2-8) | WB, ELISA, FuncS | Llama VHH |
| TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
| TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL D7) | ELISA, IHC | Single domain antibody |
| TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL C2) | ELISA, In vivo, FuncS | Single domain antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0343CL-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0343CL-S(P)) | ELISA, FuncS, In vivo | Human scFv |
| TAB-0344CL-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0344CL-S(P)) | ELISA, FuncS, In vivo | Human scFv |
| TAB-0783CLV | Human Anti-APP Recombinant Antibody (TAB-0783CLV) | ELISA, FuncS | Human IgG |
| TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
| TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
| TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
| TAB-0802CLV | Human Anti-APP Recombinant Antibody (TAB-0802CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
| TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0802CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-255CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-255CQ-S(P)) | ELISA | Mouse scFv |
| TAB-0850CLV | Mouse Anti-APP Recombinant Antibody (TAB-0850CLV) | ELISA, WB, DB | Mouse IgG3 |
| TAB-0851CLV | Mouse Anti-APP Recombinant Antibody (TAB-0851CLV) | WB, ICC, IF, ICC | Mouse IgG1 |
| TAB-0781CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0781CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0782CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0782CLV-S(P)) | ELISA | Mouse scFv |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
| PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
| MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
| MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
| MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
| EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
| EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
| EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
| EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
| NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
| NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
| NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
| NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0116CQ | Mouse Anti-APP Recombinant Antibody (HPAB-0116CQ) | ELISA, WB, IP, FuncS | Mouse IgG1, κ |
| HPAB-0117CQ | Human Anti-APP Recombinant Antibody (HPAB-0117CQ) | ELISA, WB, IP, FuncS | Human IgG1, κ |
| HPAB-0118CQ | Human Anti-APP Recombinant Antibody (clone Fv1E4) | ELISA, Inhib | Human IgG |
| HPAB-0119CQ | Human Anti-APP Recombinant Antibody (clone h12A11v1) | ELISA, CFC, FuncS | Human IgG1 |
| HPAB-0120CQ | Human Anti-APP Recombinant Antibody (HPAB-0120CQ) | ELISA, IHC, FuncS | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0116CQ-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0116CQ-F(E)) | ELISA, WB, IP, FuncS | Mouse Fab |
| HPAB-0117CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0117CQ-F(E)) | ELISA, WB, IP, FuncS | Human Fab |
| HPAB-0118CQ-F(E) | Human Anti-APP Recombinant Antibody (clone Fv1E4); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-0119CQ-F(E) | Human Anti-APP Recombinant Antibody (clone h12A11v1); Fab Fragment | ELISA, FuncS | Human Fab |
| HPAB-0120CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0120CQ-F(E)) | ELISA, IHC, FuncS | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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