Anti-Human APP Recombinant Antibody (3H3) (CAT#: TAB-0801CLV)
The anti-amyloid beta antibody 3H3 is a naturally occuring human IgG that can recognize a conformational epitope. The specific antibody can be used in the treatment of Alzheimer's Disease, family Danish dementia and other amyloid diseases.
Specific Inquiry
IHC
Figure 1 3H3 scFv expression prevents development of pathology in ADan-transgenicmice.
Newborn ADan-transgenicmice were injected into cerebral ventricles with pAAV- 3H3scFv and killed at 12 months of age.
Levites, Y., O'Nuallain, B., Puligedda, R. D., Ondrejcak, T., Adekar, S. P., Chen, C., ... & Walsh, D. M. (2015). A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. Journal of Neuroscience, 35(16), 6265-6276.
FuncS
Figure 2 mAb 3H3 is pan-reactive against immobilized Aconformers but insolution only recognizes aggregated peptide.
Antibody binding curves for 3H3 demonstrate the antibody's low nM reactivity with plate-immobilized Aconformers, 2-fold weaker binding to the monomeric peptide.
Levites, Y., O'Nuallain, B., Puligedda, R. D., Ondrejcak, T., Adekar, S. P., Chen, C., ... & Walsh, D. M. (2015). A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. Journal of Neuroscience, 35(16), 6265-6276.
Specifications
- Host Species
- Human
- Derivation
- Memory B cell
- Type
- Fully human antibody
- Specificity
- Human
- Clone
- 3H3
- Applications
- IHC, FuncS
- Related Disease
- Alzheimer's disease
Applications
- Application Notes
- The APP antibody has been reported in applications of Immunohistochemistry, Functional Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 3H3"
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-016 | Recombinant Anti-Human APP VHH Single Domain Antibody | CA, IP, IF, FuncS | Llama VHH |
| PNBL-003 | Recombinant Anti-Human APP VHH Single Domain Antibody (G7) | WB, ELISA, FuncS | Llama VHH |
| PNBL-004 | Recombinant Anti-Human APP VHH Single Domain Antibody (PS2-8) | WB, ELISA, FuncS | Llama VHH |
| PNBL-070 | Recombinant Anti-APP VHH Single Domain Antibody (KW1) | ELISA, Neut, WB, Inhibition | Llama VHH |
| TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-229 | Anti-Human Abeta Recombinant Antibody (Gantenerumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-0815CLV | Human Anti-APP Recombinant Antibody (TAB-0815CLV) | ELISA | Human IgG |
| TAB-0783CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0783CLV-S(P)) | ELISA, FuncS | Human scFv |
| TAB-0784CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0784CLV-S(P)) | ELISA | Human scFv |
| TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-254CQ | Human Anti-APP Recombinant Antibody (TAB-254CQ) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-254CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
| TAB-0802CLV | Human Anti-APP Recombinant Antibody (TAB-0802CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
| TAB-0789CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P)) | ELISA | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-253CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-253CQ-F(E)) | ELISA | Humanized Fab |
| TAB-0828CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0828CLV-F(E)) | ELISA | Humanized Fab |
| TAB-0829CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0829CLV-F(E)) | ELISA | Humanized Fab |
| TAB-0830CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0830CLV-F(E)) | ELISA | Humanized Fab |
| TAB-0831CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0831CLV-F(E)) | ELISA | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0808CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0808CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0827CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0827CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0840CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0840CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0849CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0849CLV-F(E)) | ELISA, WB, DB | Mouse Fab |
| TAB-0850CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0850CLV-F(E)) | ELISA, WB, DB | Mouse Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
| PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
| MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
| MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
| MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
| EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
| EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
| EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
| EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
| NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
| NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
| NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
| NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0116CQ | Mouse Anti-APP Recombinant Antibody (HPAB-0116CQ) | ELISA, WB, IP, FuncS | Mouse IgG1, κ |
| HPAB-0117CQ | Human Anti-APP Recombinant Antibody (HPAB-0117CQ) | ELISA, WB, IP, FuncS | Human IgG1, κ |
| HPAB-0118CQ | Human Anti-APP Recombinant Antibody (clone Fv1E4) | ELISA, Inhib | Human IgG |
| HPAB-0119CQ | Human Anti-APP Recombinant Antibody (clone h12A11v1) | ELISA, CFC, FuncS | Human IgG1 |
| HPAB-0120CQ | Human Anti-APP Recombinant Antibody (HPAB-0120CQ) | ELISA, IHC, FuncS | Human IgG1 |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-YJ-F(E) | Mouse Anti-APP Recombinant Antibody (clone 508F); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0732-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0732-FY-S(P)) | DB, ELISA | Mouse scFv |
| HPAB-0733-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0733-FY-S(P)) | DB, ELISA | Mouse scFv |
| HPAB-0735-FY-S(P) | Human Anti-APP Recombinant Antibody (clone H2L1); Fab Fragment | ELISA, FC, WB | Humanized Fab |
| HPAB-0736-FY-S(P) | Human Anti-APP Recombinant Antibody (clone H51L21); Fab Fragment | ELISA, FC, WB | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1640-FY-F(E) | Human Anti-APP Recombinant Antibody (clone 266); scFv Fragment | Cyt | Humanized scFv |
| HPAB-1641-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 6G); scFv Fragment | ELISA | Mouse scFv |
| HPAB-S0004-YC-S(P) | Human Anti-APP Recombinant Antibody (clone hu3D6); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-S0005-YC-S(P) | Human Anti-APP Recombinant Antibody (clone ch3D6); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-1828-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2324); scFv Fragment | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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