Anti-Human APP Recombinant Antibody (2B12) (CAT#: TAB-0848CLV)
The anti-APP antibody 2B12 specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.
Specific Inquiry
WB
Figure 1 Representative western blot of sAPPa incubated with or without BACE1 and 2B12, 2B3, control IgG, anti-N terminal APP IgG.
Only 2B12 and 2B3 inhibited the action of BACE1 in this system.
Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.
ELISA
Figure 2 Levels of intracellular APP as determined by ELISA.
After incubation with 2B3, 2B12, an anti-N-terminal APP IgG (N, MTS only) or a control irrelevant mouse IgG, all at 10 lgÆmL)1 for 48 h.
Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.
Specifications
- Immunogen
- Ka (spanning the β-secretase cleavage site in human APP)
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 2B12
- Applications
- WB, ELISA
- Related Disease
- Alzheimer's Disease
Applications
- Application Notes
- The APP antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-016 | Recombinant Anti-Human APP VHH Single Domain Antibody | CA, IP, IF, FuncS | Llama VHH |
| PNBL-003 | Recombinant Anti-Human APP VHH Single Domain Antibody (G7) | WB, ELISA, FuncS | Llama VHH |
| PNBL-004 | Recombinant Anti-Human APP VHH Single Domain Antibody (PS2-8) | WB, ELISA, FuncS | Llama VHH |
| PNBL-070 | Recombinant Anti-APP VHH Single Domain Antibody (KW1) | ELISA, Neut, WB, Inhibition | Llama VHH |
| TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-225 | Anti-Human Abeta Recombinant Antibody (Bapineuzumab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-226 | Anti-Human Abeta Recombinant Antibody (Crenezumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG4 - kappa |
| TAB-253CQ-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-253CQ-S(P)) | ELISA | Humanized scFv |
| TAB-0790CLV | Mouse Anti-APP Recombinant Antibody (TAB-0790CLV) | ELISA | Humanized IgG |
| TAB-0828CLV | Human Anti-APP Recombinant Antibody (TAB-0828CLV) | ELISA | Humanized antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-398 | Mouse Anti-APP Recombinant Antibody (clone 10D5); Fab Fragment | WB | Mouse Fab |
| PFBL-399 | Mouse Anti-APP Recombinant Antibody (clone 12B4); Fab Fragment | WB | Mouse Fab |
| PFBL-400 | Mouse Anti-APP Recombinant Antibody; Fab Fragment (PFBL-400) | ELISA | Mouse Fab |
| PFBL-401 | Mouse Anti-APP Recombinant Antibody (clone WO2); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| HPAB-0176-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0176-FY-F(E)) | AG | Mouse Fab, κ |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0343CL | Human Anti-APP Recombinant Antibody (TAB-0343CL) | ELISA, Inhib | Human IgG |
| TAB-0344CL | Human Anti-APP Recombinant Antibody (TAB-0344CL) | ELISA | Human IgG |
| TAB-0343CL-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0343CL-S(P)) | ELISA, FuncS, In vivo | Human scFv |
| TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
| TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-254CQ | Human Anti-APP Recombinant Antibody (TAB-254CQ) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
| TAB-254CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0789CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P)) | ELISA | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0792CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0792CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0792CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0792CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0808CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0808CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0827CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0827CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0838CLV-S(P) | Mouse Anti-Abeta protofibril Recombinant Antibody; scFv Fragment (TAB-0838CLV-S(P)) | ELISA | Mouse scFv |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
| PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
| MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
| MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
| MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
| EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
| EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
| EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
| EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
| NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
| NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
| NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
| NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0241-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0241-FY) | Inhib, FuncS | Mouse IgG1 |
| HPAB-0242-FY | Human Anti-APP Recombinant Antibody (HPAB-0242-FY) | WB | Humanized IgG1 |
| HPAB-0104-YJ | Mouse Anti-APP Recombinant Antibody (clone 5E3) | ELISA, WB, SPR | Mouse IgG1 |
| HPAB-0105-YJ | Human Anti-APP Recombinant Antibody (clone hu5E3) | ELISA, WB, SPR | Humanized IgG1 |
| HPAB-0008-YJ | Mouse Anti-APP Recombinant Antibody (clone 508F) | ELISA | Mouse IgM |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-YJ-S(P) | Mouse Anti-APP Recombinant Antibody (clone 508F); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0346-FY-S(P) | Mouse Anti-APP Recombinant Antibody (clone IBL-102); scFv Fragment | Cyt, WB, ELISA | Mouse scFv |
| HPAB-S0004-YC-S(P) | Human Anti-APP Recombinant Antibody (clone hu3D6); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-S0005-YC-S(P) | Human Anti-APP Recombinant Antibody (clone ch3D6); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-1828-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2324); scFv Fragment | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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