This immunotoxin was achieved by conjugating/fusing the Anti-ASTL Fab to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to kidney cancer and pancreatic cancer cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of kidney cancer and pancreatic cancer.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0630-YC | Mouse Anti-ASTL Recombinant Antibody (clone 7H2) | WB, IP | Mouse IgG1, κ |
HPAB-3128LY | Human Anti-ASTL Recombinant Antibody (clone SB1) | ELISA, WB, IF | Human IgG2a |
HPAB-3129LY | Human Anti-ASTL Recombinant Antibody (clone SB2) | FC, IF | Human IgG2b |
HPAB-3130LY | Human Anti-ASTL Recombinant Antibody (clone SB4) | ELISA, WB, IF | Human IgG2a |
HPAB-3131LY | Human Anti-ASTL Recombinant Antibody (clone SB5) | ELISA, WB, IF | Human IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0630-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); scFv Fragment | WB, IP | Mouse scFv |
HPAB-M0631-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 6C1); scFv Fragment | WB, IP | Mouse scFv |
HPAB-M0632-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 3F2); scFv Fragment | WB, IF | Mouse scFv |
HPAB-M0633-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 6B1); scFv Fragment | WB, IF | Mouse scFv |
HPAB-M0634-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2); scFv Fragment | WB, FC | Rabbit scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0630-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); Fab Fragment | WB, IP | Mouse Fab |
HPAB-3128LY-F(E) | Human Anti-ASTL Recombinant Antibody (clone SB1); Fab Fragment | ELISA, WB, IF | Human Fab |
HPAB-3129LY-F(E) | Human Anti-ASTL Recombinant Antibody (clone SB2); Fab Fragment | ELISA, WB, IF | Human Fab |
HPAB-3130LY-F(E) | Human Anti-ASTL Recombinant Antibody (clone SB4); Fab Fragment | ELISA, WB, IF | Human Fab |
HPAB-3131LY-F(E) | Human Anti-ASTL Recombinant Antibody (clone SB5); Fab Fragment | ELISA, WB, IF | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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