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Anti-AXL Fab (5F11) (TAB-0188CL-F(E))

The anti-Axl antibodies specifically bind to the Axl protein which belongs to the TAM (Tyro3-Axl-Mer) receptor tyrosine kinases (RTK) that share the vitamin K-dependent ligand Gas6 (growth arrest-specific 6). The binding of specific antibody to Axl can impact a series of Axl-related cellular responses including cell survival, proliferation, autophagy, migration et. Al and therefore the anti-Axl antibodies can be used to in the treatment of various solid tumours and myeloid leukaemia such as pancreatic, prostate, lung, breast, colon cancer, and acute myeloid leukaemia.      

Specifications
Immunogen
Extracellular domain of human AXL (fused to human lgG1 Fc domain)
Host
Mouse
Specificity
Human
Clone
5F11
Related Disease
Solid tumours and myeloid leukaemia
Target
Alternative Names
AXL; AXL receptor tyrosine kinase; ARK; UFO; JTK11; Tyro7
Entrez Gene ID
558
UniProt ID
P30530

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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