The anti-AXL antibody humanized 11B7 targets AXL. The antibody can be used in the treatment of cancers, such as prostate cancer and breast cancer.
Figure 1 Orthotopic xenograft model to investigate the effects of rat anti- AXL antibodies on human prostate carcinoma growth in nude mice.
PC-3-LN prostate carcinoma cells were orthotopically implanted into the prostate of NMRI-nu/nu mice. Animals were randomized into 4 groups and received 25 mg/kg of the isotypic control antibody 1 D5 or the antagonistic rat anti-AXL antibody 11B7, as well as 40 mg/kg Sutent or 12.5 mg/kg Taxotere. During the treatment period, the growth of orthotopically growing PC-3-LN tumors as well as peripheral metastases was monitored once weekly via in vivo bioluminescence imaging on day 15, day 23, day 29, and day 34. Compared to the isotypic control antibody 1 D5, the antagonistic rat anti-AXL antibody 11B7 reduced the overall growth of PC-3-LN prostate tumors in nude mice.
Figure 2 Orthotopic xenograft model to investigate the effects of rat anti- AXL antibodies on human prostate carcinoma metastasis in nude mice.
PC-3-LN prostate carcinoma cells were orthotopically implanted into the prostate of NMRI-nu/nu mice. Animals were randomized into 4 groups and received 25 mg/kg of the isotypic control antibody 1 D5 or the antagonistic rat anti-AXL antibody 11B7, as well as 40 mg/kg Sutent or 12.5 mg/kg Taxotere. Post necropsy, selected organs (liver, spleen, lung, femur, and a part of the lumbar spine) were collected and analyzed for the presence of metastases via bioluminescence imaging. Compared to the isotypic control antibody 1D5, the antagonistic rat anti-AXL antibody 11B7 reduced the occurrence of spleen metastases. Noteworthy, the anti-metastatic effect of 11 B7 in this experiment was stronger than that of Sutent.
Figure 3 This figure describes binding activity of the rat anti-human AXL humanized antibodies h#11B7-T1 to h#11B7-T6 determined by ELISA using human AXL-Fc coated plate.
Figure 4 This figure describes binding activity of the rat anti-human AXL humanized antibodies h#11B7-T7 to h#11B7-T13 determined by ELISA using human AXL-Fc coated plate.
Figure 5 This figure describes binding activity of the rat anti-human AXL humanized antibodies h#11B7-T14 to h#11B7-T20 determined by ELISA using human AXL-Fc coated plate.
Figure 6 This figure describes binding activity of the rat anti-human AXL humanized antibodies h#11B7-T21 to h#11B7-T27 determined by ELISA using human AXL-Fc coated plate.
Figure 7 This figure describes binding activity of the rat anti-human AXL humanized antibodies h#11 B7-T28 to h#11B7-T31 determined by ELISA using human AXL-Fc coated plate (ELISA).
Figure 8 These figures describes determination of Tm of the rat anti-human AXL humanized antibodies h#11B7-T1 determined by differential scanning calorimetry (DSC).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0138CL | Mouse Anti-Human AXL Recombinant Antibody (1613F12) | ELISA, IF, FC, Inhib, ICFC | |
TAB-0335CL | Anti-Human AXL Recombinant Antibody (Ax225 (was demonstrated to recognize FND1 of AXL)) | WB, FuncS, ELISA | |
TAB-0336CL | Anti-Human AXL Recombinant Antibody | WB, FuncS, ELISA | |
TAB-0335CL-S(P) | Anti-Human AXL Recombinant Antibody scFv Fragment (Ax225 (was demonstrated to recognize FND1 of AXL)) | WB, FuncS, ELISA | |
TAB-0336CL-S(P) | Anti-Human AXL Recombinant Antibody scFv Fragment | WB, FuncS, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0139CL | Anti-Human AXL Recombinant Antibody (hzl613F12-24 DAR2) | ELISA, IF, FC, Inhib, ICFC | Humanized Antibody |
TAB-0140CL | Anti-Human AXL Recombinant Antibody (hzl613F12-33 DAR4) | ELISA, IF, FC, Inhib, ICFC | Humanized Antibody |
TAB-1094CL | Anti-Human AXL Recombinant Antibody (Hz1613F12) | ELISA, FC, Cyt | Humanized antibody |
TAB-0139CL-F(E) | Anti-Human AXL Recombinant Antibody Fab Fragment (hzl613F12-24 DAR2) | ELISA, IF, FC, Inhib, ICFC | Humanized Antibody |
TAB-0140CL-F(E) | Anti-Human AXL Recombinant Antibody Fab Fragment (hzl613F12-33 DAR4) | ELISA, IF, FC, Inhib, ICFC | Humanized Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0189CL | Human Anti-AXL Recombinant Antibody (TAB-0189CL) | WB, FuncS, ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
TAB-1090CL-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (TAB-1090CL-S(P)) | ELISA, FuncS | Mouse scFv |
TAB-1091CL-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (TAB-1091CL-S(P)) | ELISA, FuncS | Mouse scFv |
TAB-1092CL-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (TAB-1092CL-S(P)) | ELISA, FuncS | Mouse scFv |
TAB-1084CLV-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1084CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3970 | Hi-Affi™ Rabbit Anti-AXL Recombinant Antibody (clone SI30DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0600-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0600-CN-F(E)) | ELISA, FC, IHC, Block | Human Fab |
HPAB-0601-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0601-CN-F(E)) | ELISA, FC, IHC, Block | Human Fab |
HPAB-0603-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0603-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
HPAB-0604-CN-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0604-CN-F(E)) | ELISA, IHC | Mouse Fab |
HPAB-0108-LS-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0108-LS-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1783LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1783LY) | ELISA, IHC | Mouse IgG2b |
HPAB-1855LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1855LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
HPAB-1856LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1856LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
HPAB-1857LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1857LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
HPAB-1858LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1858LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0021-YC-S(P) | Human Anti-AXL Recombinant Antibody (clone 9A); scFv Fragment | ELISA, FC | Human scFv |
HPAB-N0022-YC-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-N0022-YC-S(P)) | ELISA, WB, Inhib | Humanized scFv |
HPAB-0936WJ-S(P) | Rat Anti-AXL Recombinant Antibody (clone 11B7); scFv Fragment | ELISA, IHC | Rat scFv |
HPAB-0937WJ-S(P) | Rat Anti-AXL Recombinant Antibody (clone 11D5); scFv Fragment | ELISA, IHC | Rat scFv |
HPAB-0445YY-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-0445YY-S(P)) | FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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