Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) (CAT#: TAB-224)

Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Datasheet
  • MSDS
  • COA

Figure 1 Inhibition of Raxibacumab.

Figure 1 Inhibition of Raxibacumab.

Survival was significantly longer in all raxibacumab groups, and a significant dose–response trend for survival at day 14 (P<0.001) was observed.

Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., ... & Lewis, M. (2009). Raxibacumab for the treatment of inhalational anthrax. New England journal of medicine, 361(2), 135-144.

Figure 2 Raxibacumab pharmacokinetics.

Figure 2 Raxibacumab pharmacokinetics.

Plasma raxibacumab concentration-time profiles in rabbits administered 3 daily intragastric 50-mg/kg LVX doses in combination with a single i.v. 40-mg/kg raxibacumab dose. (Top) Linear scale; (bottom) semilogarithmic scale.

Migone, T. S., Bolmer, S., Zhong, J., Corey, A., Vasconcelos, D., Buccellato, M., & Meister, G. (2015). Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax. Antimicrobial agents and chemotherapy, 59(2), 1145-1151.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - lambda
  • Specificity
  • Tested positive against native B. anthracis antigen.
  • Species Reactivity
  • B. anthracis
  • Applications
  • FC, IP, ELISA, Neut, FuncS, IF, WB
  • Trade name
  • abthrax
  • CAS
  • 565451-13-0
  • Generic Name
  • Raxibacumab
  • ATC Code
  • J06BB18
  • MW
  • 142.93 kDa
  • Related Disease
  • Anthrax inhalation

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Applications

  • Application Notes
  • The B. anthracis PA antibody has been reported in applications of Inhib, PK.
    Inhibition: Doses of raxibacumab of 10 mg per kilogram or higher provided a significant benefit with respect to the primary end point, the 14-day survival rate (80 to 100%, as compared with 0% with placebo; P<0.001).

Target

  • Alternative Names
  • Raxibacumab;abthrax;565451-13-0;PA;anthrax PA;Anthrax Protective Antigen;Anthrax toxins translocating protein;Bacillus anthracis Protective Antigen;PA 83;PA;PA83;Pag;PagA;Protective antigen

Related Resources

  • Biosimilar Overview
Please refer to Raxibacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Raxibacumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Raxibacumab"

Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.

See other products for "B. anthracis PA"

Single-domain Antibody

CAT Product Name Application Type
NAB-194-VHH Recombinant Anti-B. anthracis PA VHH Single Domain Antibody WB, ICC, ChiP, FA, ELISA Llama VHH

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0387LC Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) BL, ELISA IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-224 Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-440CQ Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-224. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare