Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
Figure 1 Inhibition of Raxibacumab.
Survival was significantly longer in all raxibacumab groups, and a significant dose–response trend for survival at day 14 (P<0.001) was observed.
Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., ... & Lewis, M. (2009). Raxibacumab for the treatment of inhalational anthrax. New England journal of medicine, 361(2), 135-144.
Figure 2 Raxibacumab pharmacokinetics.
Plasma raxibacumab concentration-time profiles in rabbits administered 3 daily intragastric 50-mg/kg LVX doses in combination with a single i.v. 40-mg/kg raxibacumab dose. (Top) Linear scale; (bottom) semilogarithmic scale.
Migone, T. S., Bolmer, S., Zhong, J., Corey, A., Vasconcelos, D., Buccellato, M., & Meister, G. (2015). Added benefit of raxibacumab to antibiotic treatment of inhalational anthrax. Antimicrobial agents and chemotherapy, 59(2), 1145-1151.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-97-F(E) | Recombinant Anti-B. anthracis PA Antibody Fab Fragment | RIA, IP, FuncS | Fab |
HPAB-1646-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1646-FY-S(P)) | ELISA | Human scFv |
HPAB-1647-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1647-FY-S(P)) | ELISA | Human scFv |
HPAB-1648-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1648-FY-S(P)) | ELISA | Human scFv |
FAMAB-0223JF-F(E) | Monkey Anti-B. anthracis PA Recombinant Antibody (clone 35PA83); Fab Fragment | ELISA, FuncS | Monkey Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0387LC | Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) | BL, ELISA | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-224 | Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-440CQ | Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1646-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1646-FY) | Neut, ELISA, Inhib | Human IgG |
HPAB-1647-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1647-FY) | Neut | Human IgG |
HPAB-1648-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1648-FY) | Inhib | Human IgG |
HPAB-1824-FY | Human Anti-B. anthracis PA Recombinant Antibody (clone 21D9) | Inhib | Human IgG |
ZG-0292F | Mouse Anti-B. anthracis PA Recombinant Antibody (ZG-0292F) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1826-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 4H7); scFv Fragment | ELISA | Human scFv |
HPAB-0747-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W1); scFv Fragment | ELISA, Neut | Chimpanzee scFv |
HPAB-0748-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W2); scFv Fragment | ELISA, WB, Neut, FuncS | Chimpanzee scFv |
FAMAB-0048JF-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C); scFv Fragment | WB, ELISA, FuncS | Human scFv |
FAMAB-0333JF-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1); scFv Fragment | ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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