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Anti-B-cell immunotoxin SN7 (IgG)-RTA (AGTO-G073R)

This immunotoxin was achieved by conjugating/fusing the Anti-B-cell monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of B-Cell leukemia.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
SN7
Molecule Class
L kappa; IgG-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
B-Cell leukemia
Target
Alternative Names
B lymphocytes; B cell; B-cell; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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