Anti-Human BDKRB2 Recombinant Antibody (5F12G1) (CAT#: TAB-1264CL)

Figure 1 A graph of acute monoclonal antibody dose response.

The graph plots the average mean arterial pressure response for all four indicated anti-BKB2R monoclonal antibody groups following infusion. Data points for each group are presented as mean ± Standard Error.

Figure 2 A graph depicting the effect of anti-BKB2R monoclonal antibodies on blood pressure one, two and three hours after in vivo administration.

The graph plots the mean ± SEM for each group (*p<0.05 vs baseline for 5F12G1 ).

Figure 3 The glucose infusion rate of monoclonal anti-BKB2R antibody F512G1 in the hyperinsulinemic euglycemic clamps, compared to a vehicle control.

Figure 4 The blood glucose levels during an oral glucose tolerance test in Zucker rats treated with various doses of monoclonal antibody 5F12G1.

Figure 5 The serum insulin levels during an oral glucose tolerance test in Zucker rats treated with various doses of monoclonal antibody 5F12G1.

Figure 6 The blood glucose levels during an oral glucose tolerance test in DIO mice treated with various doses of monoclonal antibody 5F12G1.

Figure 7 Figure A shows the blood glucose levels during an oral glucose tolerance test in ZDF fa/fa rats at day 0, and figure B shows the blood glucose levels during an oral glucose tolerance test on day 21, after treatment with various doses of monoclonal antibody 5F12G1, exenatide, sitagliptin or MG2b-57.

Figure 8 The area under the curve (AUC) of blood glucose levels in ZDF fa/fa rats during an oral glucose tolerance on day 21 after treatment with various doses of 5F12G1, exenatide, sitagliptin or MG2b-57.

Figure 9 Figure A shows the serum insulin levels during an oral glucose tolerance test in ZDF fa/fa rats at day 0, and figure B shows serum insulin levels during an oral glucose tolerance test in ZDF fa/fa rats on day 21, after treatment with various doses of monoclonal antibody 5F12G1, exenatide, sitagliptin or MG2b-57.

Figure 10 The area under the curve (AUC) data from an oral glucose tolerance test that monitored blood glucose concentration following single administration of 5F12G1 or humanized anti-BKB2R monoclonal antibodies, after oral administration of glucose in ZDF fa/fa rats, as compared to a vehicle control.