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  • Recombinant Anti-human BMX Intrabody [(D-Arg)9]

Recombinant Anti-human BMX Intrabody [(D-Arg)9] (CAT#: IAB-B077(A))

Recombinant anti-BMX intrabody linked to (D-Arg)9 works within cells to bind intracellur antigen BMX, expressed in 293T cells. These antibodiess bind specifically to recombinant BMX and efficiently block its kinase activity. When expressed in transformed cells, these antibodiess associated tightly with Etk, leading to significant blockade of Etk enzymatic activity and inhibition of clonogenic cell growth in soft agar.


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Subcellular Location
Figure 1 IF staining of human cell line HUVEC TERT2
Figure 1 IF staining of human cell line HUVEC TERT2
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/1751_G2_18_cr58009842c82e5_selected.jpg
Normal Tissue
Figure 2 Epididymis
Figure 2 Epididymis
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_A_1_6.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_A_9_3.jpg
Figure 5 Testis
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HUVEC TERT2)
Figure 6 RNA cell line category: Cell line enriched (HUVEC TERT2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102010-BMX

Specifications

  • Immunogen
  • human BMX non-receptor tyrosine kinase
  • Host Species
  • human
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Products can be used for: Coimmunopricipation; Functional studies

Product Property

  • Purity
  • >95% (SDS-PAGE)
  • Storage
  • Short Term Storage: 4°C
    Long Term Storage: -20°C

Target

  • Alternative Names
  • BMX; BMX non-receptor tyrosine kinase; ETK; PSCTK2; PSCTK3; cytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; BTK-like on X chromosome; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinas

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "BMX"

Intrabody

CAT Product Name Application Type
IAB-B077(G) Recombinant Anti-human BMX Intrabody [+36 GFP] IF, ELISA, FuncS scFv-Tat
IAB-B077(T) Recombinant Anti-human BMX Intrabody [Tat] FC, IF, FuncS scFv-Tat

Recombinant Antibody

CAT Product Name Application Type
MOB-1504MZ Mouse Anti-BMX Recombinant Antibody (clone 2D7) ELISA, WB Mouse IgG1
ZG-0342F Mouse Anti-Bmx Recombinant Antibody (ZG-0342F) WB, ELISA Mouse IgG
VS3-QX126 Mouse Anti-BMX Recombinant Antibody (clone 1C6) WB, IHC, ICC, FC, ELISA Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0372 Hi-Affi™ Rabbit Anti-BMX Recombinant Antibody (clone DS372AB) WB, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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