Recombinant Anti-human BMX Intrabody [Tat] (CAT#: IAB-B077(T))

Recombinant anti-BMX intrabody in fusion with HIV Tat works within cells to bind intracellur antigen BMX, expressed in 293T cells. These antibodiess bind specifically to recombinant BMX and efficiently block its kinase activity. When expressed in transformed cells, these antibodiess associated tightly with Etk, leading to significant blockade of Etk enzymatic activity and inhibition of clonogenic cell growth in soft agar.


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human BMX non-receptor tyrosine kinase
  • Host Species
  • human
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • human
  • Applications
  • Formats of immunological tests: Flow Cytometry; Immunofluorescence; Functional studies

Product Property

  • Purity
  • 95% by HPLC
  • Storage
  • ≤1 year at -20°C.

Target

  • Alternative Names
  • BMX; BMX non-receptor tyrosine kinase; ETK; PSCTK2; PSCTK3; cytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; BTK-like on X chromosome; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinas

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "BMX"

Intrabody

CAT Product Name Application Type
IAB-B077(A) Recombinant Anti-human BMX Intrabody [(D-Arg)9] CO-IP, FuncS scFv-(D-Arg)9
IAB-B077(G) Recombinant Anti-human BMX Intrabody [+36 GFP] IF, ELISA, FuncS scFv-Tat

Recombinant Antibody

CAT Product Name Application Type
MOB-1504MZ Mouse Anti-BMX Recombinant Antibody (clone 2D7) ELISA, WB Mouse IgG1
ZG-0342F Mouse Anti-Bmx Recombinant Antibody (ZG-0342F) WB, ELISA Mouse IgG
VS3-QX126 Mouse Anti-BMX Recombinant Antibody (clone 1C6) WB, IHC, ICC, FC, ELISA Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0372 Hi-Affi™ Rabbit Anti-BMX Recombinant Antibody (clone DS372AB) WB, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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