Recombinant Mouse Anti-C.neoformans Antibody (2H1) (CAT#: PABX-021)

Anti-C. neoformans antibody is a Mouse antibody of IgG1 κ class that binds to an C. neoformans. This antibody recognizes the 12 amino acid residue peptide PA1 (GLQYTPSWMLVG).


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IHC

Figure 1 Histopathology of lung following IT infection with C. neoformans stained with H&E or mucicarmine (insets), which stains capsular polysaccharide.

Figure 1 Histopathology of lung following IT infection with C. neoformans stained with H&E or mucicarmine (insets), which stains capsular polysaccharide.

Mice were treated with PBS or purified mAb 2H1 24 h before infection. mAb 2H1-treated parental mice, day 14. Granulomatous inflammation is seen with fewer cryptococci in airspaces. The inflammatory cells include polymorphonuclear leukocytes, lymphocytes, epithelioid cells, and macrophages.

Rivera, J., Mukherjee, J., Weiss, L. M., & Casadevall, A. (2002). Antibody efficacy in murine pulmonary Cryptococcus neoformans infection: a role for nitric oxide. The Journal of Immunology, 168(7), 3419-3427.

FuncS

Figure 2 Phagocytosis of C. neoformans 24067 and 371 by J774.16 cells in the presence and absence of MAbs 18B7 and 2H1.

Figure 2 Phagocytosis of C. neoformans 24067 and 371 by J774.16 cells in the presence and absence of MAbs 18B7 and 2H1.

Each point is the average of three measurements.

Casadevall, A., Cleare, W., Feldmesser, M., Glatman-Freedman, A., Goldman, D. L., Kozel, T. R., ... & Rosas, A. L. (1998). Characterization of a Murine Monoclonal Antibody toCryptococcus neoformans Polysaccharide That Is a Candidate for Human Therapeutic Studies. Antimicrobial agents and chemotherapy, 42(6), 1437-1446.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native C.neoformans
  • Species Reactivity
  • Cryptococcus neoformans
  • Clone
  • 2H1
  • Applications
  • WB, ELISA, FuncS, IHC, FuncS

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The C.neoformans antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Functional Assay, Immunohistochemistry, Functional Assay.

Target

  • Alternative Names
  • C. neoformans, Cryptococcus neoformans

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-244 Recombinant Anti-C. neoformans Antibody WB, ELISA, IHC, FuncS IgG
MHH-244 Recombinant Human Anti-C. neoformans Antibody WB, FuncS IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-244-F(E) Recombinant Anti-C. neoformans Antibody Fab Fragment ELISA, RIA, FuncS Fab
MHH-244-F(E) Recombinant Human Anti-C. neoformans Antibody Fab Fragment IP, IF, Biosensors, FuncS Fab

scFv Fragment Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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