Anti-Human CA9 Recombinant Antibody (MSC8) (CAT#: TAB-1463CL)

This antibody, which can bind to Carbonic Anhydrase IX (CAIX), is useful in the diagnosis and treatment of cancer and in conditions associated with hypoxia and/or elevated CAIX activity.


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
SPR

Figure 1 Affinity of Fab MSC 8 as monitored by surface plasmon resonance.

Figure 1 Affinity of Fab MSC 8 as monitored by surface plasmon resonance.

Serial dilutions of purified Fab were injected on a rhCAIX-coated CM5 sensor chip. Values were corrected for binding to the reference flow cell. The solid lines represent the theoretical curves for each Fab concentration calculated according to the 1 : 1 binding model. KA, ¾ and KD values calculated by the 1 : 1 binding model are shown in the table.

ELISA

Figure 2 Confirmation of selectivity of the selected antibodies.

Figure 2 Confirmation of selectivity of the selected antibodies.

Antibody binding to carbonic anhydrase isoforms II, IV, IX, XII and XIV was analyzed in ELISA on recombinant proteins. ESC1 1 IgG recognizing human fibroblast activation protein served as negative control. Coating was confirmed by staining with a Penta-His antibody. Absorbance at 450 nm (A450) is shown for one representative experiment using MSC 8 IgG. Samples were measured in triplicate. Significance was assessed using a paired two-tailed T-test. **: P < 0.01.

Figure 3 Carbonic anhydrase activity, normalized to a scale where activity measured in HCTl 16-CAIX and HCTl 16-EV membrane fragments are one and zero, respectively.

Figure 3 Carbonic anhydrase activity, normalized to a scale where activity measured in HCTl 16-CAIX and HCTl 16-EV membrane fragments are one and zero, respectively.

Asterisks denote significant reduction in activity (MSC5, MSC 10„MSC12 and MSC8 Fab antibodies).


Specifications

  • Host Species
  • Human
  • Type
  • Fully human antibody
  • Specificity
  • Human
  • Clone
  • MSC8
  • Applications
  • ELISA, SPR
  • Related Disease
  • Cancer

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-Linked Immunosorbent Assay and Surface Plasmon Resonance.

Target

  • Alternative Names
  • MN; CAIX

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone MSC8"

See other products for "CA9"

Recombinant Antibody

CAT Product Name Application Type
MOB-1276z Mouse Anti-CA9 Recombinant Antibody (clone 21C7) ELISA, FC, IHC, WB Mouse IgG1, κ
HPAB-0104-LSX Human Anti-CA9 Recombinant Antibody (HPAB-0104-LSX) ELISA, FC, Inhib Human IgG
HPAB-0105-LSX Human Anti-CA9 Recombinant Antibody (HPAB-0105-LSX) ELISA, FC, Inhib Human IgG
HPAB-0782-CN Human Anti-CA9 Recombinant Antibody (clone G119) FC, ELISA, Inhib, Cyt, Bioimaging Human IgG
HPAB-0784-CN Human Anti-CA9 Recombinant Antibody (clone G37) FC, ELISA, Inhib, FuncS, Cyt, Bioimaging, IHC Human IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-707 Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1 - kappa
TAB-H43 Anti-Human CA9 Recombinant Antibody (Iodine (124I) Girentuximab) ELISA, IP, IF, Inhib IgG1 - kappa

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0427 Hi-Affi™ Rabbit Anti-CA9 Recombinant Antibody (clone DS427AB) IHC-P, WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H43 Afuco™ Anti-CA9 ADCC Recombinant Antibody (Girentuximab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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