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  • Recombinant Anti-human CASP3 Intrabody [(D-Arg)9]

Recombinant Anti-human CASP3 Intrabody [(D-Arg)9] (CAT#: IAB-B002(A))

Recombinant anti-CASP3 intrabody linked to (D-Arg)9 works within cells and specifically binds to pro-apoptotic protein CASP3, expressed in CHO cells. These intrabodies are useful drugs on their own as well as a means for identifying small compound drugs for degenerative diseases involving oxidative-stress-induced apoptosis.


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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2643/2013_E2_2_selected.jpg
Figure 2 IHC staining of human adrenal gland
Figure 2 IHC staining of human adrenal gland
(Immunohistochemical staining of human adrenal gland shows strong cytoplasmic positivity in granular pattern in cortical cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/91/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2643/2_C1_1_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2643/3_C1_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Figure 5 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8381/20562_A_9_3.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Preleptotene spermatocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8381/20562_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8381/20562_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Karpas-707)
Figure 8 RNA cell line category: Cell line enhanced (Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164305-CASP3
Figure 8 RNA cell line category: Cell line enhanced (Karpas-707)
Figure 8 RNA cell line category: Cell line enhanced (Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164305-CASP3

Specifications

  • Immunogen
  • human caspase 3, apoptosis-related cysteine peptidase
  • Host Species
  • llama
  • Type
  • vhh-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Antibody assay: Western blot; Immunocytochemistry; Functional studies

Product Property

  • Purity
  • >98% by SDS-PAGE and HPLC analysis
  • Storage
  • 4°C or -20°C, avoid repeated freezing and thawing.

Target

  • Alternative Names
  • CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine

Related Resources

  • Related Signaling Pathways
  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CASP3"

Single-domain Antibody

CAT Product Name Application Type
NABG-037 Recombinant Anti-Human CASP3 VHH Single Domain Antibody WB, ELISA, IHC, FuncS Llama VHH

Intrabody

CAT Product Name Application Type
IAB-B002(G) Recombinant Anti-human CASP3 Intrabody [+36 GFP] ICC, Neut, FuncS vhh-(+36GFP)
IAB-B002(T) Recombinant Anti-human CASP3 Intrabody [Tat] ELISA, WB, ICC, FuncS vhh-Tat

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0475 Hi-Affi™ Rabbit Anti-CASP3 Recombinant Antibody (clone DS475AB) IF, IHC-Fr, IHC-P, WB Rabbit IgG
MOR-4541 Hi-Affi™ Rabbit Anti-CASP3 Recombinant Antibody (clone TH50DS) WB, IF, ICC, IHC-P, FC Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
MRO-1720-CN Rabbit Anti-CASP3 Polyclonal Antibody (MRO-1720-CN) WB, IF, IHC, FC Rabbit IgG
MRO-1721-CN Rabbit Anti-CASP3 Polyclonal Antibody (MRO-1721-CN) WB, IF, IHC, FC Rabbit IgG
VS3-QX154 Mouse Anti-CASP3 Recombinant Antibody (clone 4A3-10B6-7F7) WB, IHC Mouse IgG1
VS3-QX155 Mouse Anti-CASP3 Recombinant Antibody (clone 1B10-10E2-6A5) IHC Mouse IgG1
VS3-QX156 Mouse Anti-CASP3 Recombinant Antibody (clone 5H3-3H7-7G2) IHC Mouse IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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