Anti-Human CCR2 Recombinant Antibody (MLN1202) (CAT#: TAB-099CL)

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human CCR2. MLN1202 is a humanized monoclonal antibody with high specificity to CCR2, which interrupts MCP-1 binding to CCR2. MLN1202 is being developed for the treatment of immune mediated diseases.


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  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Mean serum concentrations of MLN1202 per dose group over time.

Figure 1 Mean serum concentrations of MLN1202 per dose group over time.

Arrows indicate the times of intravenous infusion with MLN1202. Serial samples were assessed on the days of infusion, and single samples were assessed on the other days.

Vergunst, C. E., Gerlag, D. M., Lopatinskaya, L., Klareskog, L., Smith, M. D., Van den Bosch, F., ... & Baeten, D. (2008). Modulation of CCR2 in rheumatoid arthritis: a double‐blind, randomized, placebo‐controlled clinical trial. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 58(7), 1931-1939.

Figure 2 Mean occupancy rates of CCR2 on peripheral blood monocytes per dose group over time.

Figure 2 Mean occupancy rates of CCR2 on peripheral blood monocytes per dose group over time.

Rates were first calculated per patient as a percentage increase in occupied CCR2 receptors as compared with that before the first infusion with MLN1202. Free CCR2 decreased significantly (P<0.001) in all MLN1202-treated groups. CCR2 blockade in the 1.5 mg/kg and 4.0 mg/kg groups was demonstrated by a mean decrease of free CCR2 over 43 days of 86% and 94%, respectively

Vergunst, C. E., Gerlag, D. M., Lopatinskaya, L., Klareskog, L., Smith, M. D., Van den Bosch, F., ... & Baeten, D. (2008). Modulation of CCR2 in rheumatoid arthritis: a double‐blind, randomized, placebo‐controlled clinical trial. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 58(7), 1931-1939.

Figure 3 Relationship between mean MLN1202 serum concentration and pharmacodynamic response expressed as the change in mean equivalent of soluble fluorescence (MESF) in the Mu1D9 free-site assay.

Figure 3 Relationship between mean MLN1202 serum concentration and pharmacodynamic response expressed as the change in mean equivalent of soluble fluorescence (MESF) in the Mu1D9 free-site assay.

A reduction in the MESF indicates a reduction in free CCR2 on peripheral blood monocytes. The oval shape indicates the serum concentration range (trough levels included) attained using the 2 highest dose levels of MLN1202 from day 1 through day 43; boldface values with arrows show the point at which 90% of the total MESF response (indicating CCR2 receptor saturation) was achieved.

Vergunst, C. E., Gerlag, D. M., Lopatinskaya, L., Klareskog, L., Smith, M. D., Van den Bosch, F., ... & Baeten, D. (2008). Modulation of CCR2 in rheumatoid arthritis: a double‐blind, randomized, placebo‐controlled clinical trial. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 58(7), 1931-1939.

FuncS

Figure 4 Dose-dependent increase in serum levels of the CCR2 ligand, CCL2, in MLN1202-treated patients.

Figure 4 Dose-dependent increase in serum levels of the CCR2 ligand, CCL2, in MLN1202-treated patients.

Results are the mean and SD fold increase from day 1 (d1) pretreatment. The absolute pretreatment (day 1) serum levels were comparable between all 4 patient groups (P=0.97). The increase in CCL2 was statistically significant in the 2 highest dose level groups when compared with that in the placebo group; however, the difference between the 2 highest dose level groups did not reach statistical significance.

Vergunst, C. E., Gerlag, D. M., Lopatinskaya, L., Klareskog, L., Smith, M. D., Van den Bosch, F., ... & Baeten, D. (2008). Modulation of CCR2 in rheumatoid arthritis: a double‐blind, randomized, placebo‐controlled clinical trial. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 58(7), 1931-1939.


Specifications

  • Derivation
  • Humanized
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • FuncS
  • Related Disease
  • Atherosclerosis; Multiple Sclerosis

Product Property

  • Purity
  • >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Applications

  • Application Notes
  • The antibody was validated for Functional Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • CCR2; chemokine (C-C motif) receptor 2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Rabbit Monoclonal Antibody

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Humanized Antibody

CAT Product Name Application Type
TAB-444CQ Anti-Human CCR2 Recombinant Antibody (Plozalizumab) ELISA, IHC, FC, IP, IF, Inhib IgG1, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
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