Afuco™ Anti-Human CCR4 ADCC Recombinant Antibody (AT008), ADCC Enhanced (CAT#: AFC-096CL)
Anti-CCR4 ADCC Enhanced Antibody (AT008) is an ADCC enhanced antibody produced by our Afuco™ platform. AT008 is a GPCR antibody program for chemokine receptor CCR4 as a potential treatment targeted against certain haematological and solid cancers.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/329_F5_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/329_F5_2_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in a subset of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in a subset of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/ihc_selected.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_8_3.jpg
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_4_6.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_9_8.jpg
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183813-CCR4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183813-CCR4
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- CCR4; chemokine (C-C motif) receptor 4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4
- Gene ID
- 1233
- UniProt ID
- A0N0Q1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1992z | Mouse Anti-CCR4 Recombinant Antibody (clone 42C4) | WB, FC, ICC, IF | Mouse IgG2a |
| HPAB-0141-LSX | Mouse Anti-CCR4 Recombinant Antibody (HPAB-0141-LSX) | ELISA, WB, FC, ADCC, CDC, FuncS | Mouse IgG2b |
| HPAB-0143-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0143-LSX) | ELISA, WB, FC, ADCC, CDC, FuncS | Human IgG |
| HPAB-0144-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0144-LSX) | ELISA, WB, FC, ADCC, CDC | Human IgG |
| HPAB-0145-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0145-LSX) | ELISA, WB, FC, ADCC, CDC | Human IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-187 | Human Anti-CCR4 Recombinant Antibody (TAB-187) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG1, κ |
| TAB-1530CL | Human Anti-CCR4 Recombinant Antibody (TAB-1530CL) | Depletion, FuncS | Human IgG4 |
| TAB-1530CL-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (TAB-1530CL-S(P)) | Depletion, FuncS | Human scFv |
| TAB-1530CL-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (TAB-1530CL-F(E)) | Depletion, FuncS | Humanized Fab |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G005D | Anti-CCR4 immunotoxin (scFv)-DT | Cytotoxicity assay, Function study |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-142 | Human Anti-CCR4 Recombinant Antibody (clone KM3060); Fab Fragment | WB | Chimeric (mouse/human) Fab |
| HPAB-0141-LSX-S(P) | Mouse Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-0141-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-1109WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-1109WJ-S(P)) | FC | Humanized scFv |
| HPAB-1268WJ-S(P) | Mouse Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-1268WJ-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-1370WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (clone KM2760) | ELISA, WB | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1524CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (406) | FC, Inhib | Human antibody |
| TAB-1525CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (501) | FC, Inhib | Human antibody |
| TAB-1526CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (503) | FC, Inhib | Human antibody |
| TAB-1527CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (601) | FC, Inhib | Human antibody |
| TAB-1528CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (603) | FC, Inhib | Human antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0141-LSX-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0141-LSX-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0143-LSX-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0143-LSX-F(E)) | ELISA, WB, FC | Humanized Fab |
| HPAB-0144-LSX-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0144-LSX-F(E)) | ELISA, WB, FC | Humanized Fab |
| HPAB-0145-LSX-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0145-LSX-F(E)) | ELISA, WB, FC | Humanized Fab |
| HPAB-0146-LSX-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0146-LSX-F(E)) | ELISA, IF | Chimeric (mouse/human) Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-187 | Afuco™ Anti-CCR4 Recombinant Antibody (AFC-TAB-187), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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