This immunotoxin was achieved by conjugating/fusing the Anti-CCR4 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CCR4+ tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of T-cell acute lymphoblastic leukemia (ALL); adult T-cell leukemia/lymphoma (ATLL); adult peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-187 | Human Anti-CCR4 Recombinant Antibody (TAB-187) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG1, κ |
TAB-1530CL | Human Anti-CCR4 Recombinant Antibody (TAB-1530CL) | Depletion, FuncS | Human IgG4 |
TAB-1530CL-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (TAB-1530CL-S(P)) | Depletion, FuncS | Human scFv |
TAB-1530CL-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (TAB-1530CL-F(E)) | Depletion, FuncS | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABZ-142 | Human Anti-CCR4 Recombinant Antibody (clone KM3060) | WB | Chimeric (mouse/human) IgG1, κ |
HPAB-1109WJ | Human Anti-CCR4 Recombinant Antibody (HPAB-1109WJ) | ELISA, FC | Humanized IgG1 |
HPAB-1268WJ | Mouse Anti-CCR4 Recombinant Antibody (HPAB-1268WJ) | FC, IHC | Mouse IgG |
MOB-213YJL | Chimeric (Mouse/Human) Anti-CCR4 Recombinant Antibody (clone chKM2760) | ELISA, FC, FuncS | Chimeric (mouse/human) IgG1, κ |
VS-0723-WK160 | Human Anti-CCR4 Recombinant Antibody (VS-0723-WK160) | FC | Chimeric (rabbit/human) IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1521CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (208) | FC, Inhib | Human antibody |
TAB-1522CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (306) | FC, Inhib | Human antibody |
TAB-1523CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (308) | FC, Inhib | Human antibody |
TAB-1524CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (406) | FC, Inhib | Human antibody |
TAB-1525CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (501) | FC, Inhib | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0047-FY-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-0047-FY-S(P)) | FC | Human scFv |
HPAB-1004WJ-S(P) | Human Anti-CCR4 Recombinant Antibody (clone 17G); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1005WJ-S(P) | Human Anti-CCR4 Recombinant Antibody (clone 9E); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1109WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-1109WJ-S(P)) | FC | Humanized scFv |
HPAB-1370WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (clone KM2760) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1777LY-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1777LY-F(E)) | FC, Inhib, ELISA | Mouse Fab |
HPAB-1778LY-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1778LY-F(E)) | FC, Inhib, ELISA | Mouse Fab |
HPAB-1779LY-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1779LY-F(E)) | FC, Inhib, ELISA | Mouse Fab |
HPAB-1780LY-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1780LY-F(E)) | FC, Inhib, ELISA | Humanized Fab |
HPAB-1004WJ-F(E) | Human Anti-CCR4 Recombinant Antibody (clone 17G); Fab Fragment | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-187 | Afuco™ Anti-CCR4 Recombinant Antibody (AFC-TAB-187), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1, κ |
There are currently no Customer reviews or questions for AGTO-G005D. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.