Human Anti-CCR5 Recombinant Antibody (clone huPR0140) (CAT#: HPAB-0047-YC)

The CC-chemokine receptor CCR5 is the major co-receptor for macrophage-tropic (R5) strains, and plays a crucial role in the sexual transmission of HIV-1 (4, 5, 21, 36). T cell line-tropic (X4) viruses use CXCR4 to enter target cells, and usually, but not always, emerge late in disease progression or as a consequence of virus propagation in tissue culture. Anti-CCR5 monoclonal antibodies have also shown the importance of the extracellular loops for viral entry


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 pro 140 serum concentrations following a single intrawennous injection in HIV-infected invidulas

Figure 1 pro 140 serum concentrations following a single intrawennous injection in HIV-infected invidulas

Provides PRO 140 serum concentrations following a single intravenous injection in HIV-infected individuals,and shows differences between 0.5 mg/kg (rep resented by a square),2 mg/kg (represented by a triangle, and 5 mg/kg (represented by a diamond) amounts.

Figure 2 emax analysis of antiviral data generated with IV and SC PRO 140, measure as Logo change in HIV-1 RNA versus AUC, mg * day/mL

Figure 2 emax analysis of antiviral data generated with IV and SC PRO 140, measure as Logo change in HIV-1 RNA versus AUC, mg * day/mL


Specifications

  • Immunogen
  • Immunized with L1.2-CCR5+ cells
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized IgG
  • Specificity
  • Human CCR5
  • Species Reactivity
  • Human
  • Clone
  • huPR0140
  • Applications
  • Block

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; C-C Motif Chemokine Receptor 5 A159A; Chemokine (C-C Motif) Receptor 5; Chemokine Receptor CCR5; CD195 Antigen; C-C CKR-5; CCCKR5; IDDM22; CD195; CKR-5; CKR5

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone huPR0140"

See other products for "CCR5"

Single-domain Antibody

CAT Product Name Application Type
NABL-078 Recombinant Anti-mouse Ccr5 VHH Single Domain Antibody WB, ELISA, IP, FuncS Llama VHH

Intrabody

CAT Product Name Application Type
IAB-B039(A) Recombinant Anti-human CCR5 Intrabody [(D-Arg)9] PCA, WB, FuncS scFv-(D-Arg)9
IAB-B039(G) Recombinant Anti-human CCR5 Intrabody [+36 GFP] FACS, ELISA, IF, FuncS scFv-(+36GFP)
IAB-B039(T) Recombinant Anti-human CCR5 Intrabody [Tat] FACS, ICC, FuncS scFv-Tat

Humanized Antibody

CAT Product Name Application Type
TAB-10000S Anti-Human CCR5 Recombinant Antibody IF, IP, Neut, FuncS, ELISA, FC, ICC IgG4

Fc Glycosylation

CAT Product Name Application Type
Gly-106LC Recombinant Anti-Human CCR5 Antibody (Fc glycosylation) ELISA Mouse antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-267CQ Mouse Anti-CCR5 Recombinant Antibody (clone 45523.111) FC, IHC-P, Neut Mouse IgG2b
NEUT-268CQ Mouse Anti-CCR5 Recombinant Antibody (clone CBL472) FC, CyTOF, ICC, Neut Mouse IgG2b
NEUT-269CQ Mouse Anti-CCR5 Recombinant Antibody (clone MM0681-7D32) FC, IHC-P, Neut Mouse IgG2

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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