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Anti-CCR5 Intrabody [+36GFP] (IAB-B039(G))

Recombinant anti-CCR5 intrabody in fusion with +36GFP works within cells and is directed against human CCR5, expressed in 293T cells. CCR5-intrabody efficiently blocked surface expression of human CCR5 and thus prevented cellular interactions with CCR5-dependent HIV-1 and simian immunodeficiency virus envelope glycoprotein.      

Specifications
Immunogen
human chemokine (C-C motif) receptor 5 (gene/pseudogene)
Host
rabbit
Type
scFv-(+36GFP)
Cell Penetrating Peptide
+36 GFP
GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
Species Reactivity
human
Applications
Formats of immunological tests: Fluorescence-activated cell sorting; Enzyme-linked Immunosorbent Assay; Immunofluorescence; Functional studies
Target
Alternative Names
CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5
Entrez Gene ID
1234
UniProt ID
P51681

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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