Recombinant Anti-human CCR5 Intrabody [(D-Arg)9] (CAT#: IAB-B039(A))
Recombinant anti-CCR5 intrabody linked to (D-Arg)9 works within cells and binds specifically to human CCR5, expressed in 293T cells. CCR5-intrabody efficiently blocked surface expression of human CCR5 and thus prevented cellular interactions with CCR5-dependent HIV-1 and simian immunodeficiency virus envelope glycoprotein.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
Specifications
- Immunogen
- human chemokine (C-C motif) receptor 5 (gene/pseudogene)
- Host Species
- rabbit
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Protein fragment complementation; Western blot; Functional studies
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A
- Gene ID
- 1234
- UniProt ID
- P51681
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CCR5"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-078 | Recombinant Anti-mouse Ccr5 VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B039(G) | Recombinant Anti-human CCR5 Intrabody [+36 GFP] | FACS, ELISA, IF, FuncS | scFv-(+36GFP) |
| IAB-B039(T) | Recombinant Anti-human CCR5 Intrabody [Tat] | FACS, ICC, FuncS | scFv-Tat |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-10000S | Anti-Human CCR5 Recombinant Antibody | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1531CL | Human Anti-CCR5 Recombinant Antibody (TAB-1531CL) | FuncS | Human IgG4 |
| TAB-1531CL-F(E) | Human Anti-CCR5 Recombinant Antibody; Fab Fragment (TAB-1531CL-F(E)) | FuncS | Human Fab |
| TAB-1532CL-F(E) | Human Anti-CCR5 Recombinant Antibody; Fab Fragment (TAB-1532CL-F(E)) | FuncS | Human Fab |
| TAB-1533CL-F(E) | Anti-Human CCR5 Recombinant Antibody Fab Fragment (15.186.35) | ELISA, WB | Human antibody |
| TAB-1534CL-F(E) | Anti-Human CCR5 Recombinant Antibody Fab Fragment (15.150.11) | ELISA, WB | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1535CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1535CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-1536CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1536CL-S(P)) | ELISA | Mouse scFv |
| TAB-1537CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1537CL-S(P)) | ELISA | Mouse scFv |
| TAB-1538CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1538CL-S(P)) | ELISA | Mouse scFv |
| TAB-1539CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1539CL-S(P)) | ELISA | Mouse scFv |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-106LC | Recombinant Anti-Human CCR5 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-267CQ | Mouse Anti-CCR5 Recombinant Antibody (clone 45523.111) | FC, IHC-P, Neut | Mouse IgG2b |
| NEUT-268CQ | Mouse Anti-CCR5 Recombinant Antibody (clone CBL472) | FC, CyTOF, ICC, Neut | Mouse IgG2b |
| NEUT-269CQ | Mouse Anti-CCR5 Recombinant Antibody (clone MM0681-7D32) | FC, IHC-P, Neut | Mouse IgG2 |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-017CN | Mouse Anti-CCR5 Recombinant Antibody (clone PA14) | ELISA, WB, FC | Mouse IgG1 |
| NS-017CN-F(E) | Mouse Anti-CCR5 Recombinant Antibody (clone PA14); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| NS-017CN-S(P) | Mouse Anti-CCR5 Recombinant Antibody (clone PA14); scFv Fragment | ELISA, WB, FC | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131CQ | Mouse Anti-CCR5 Recombinant Antibody (HPAB-0131CQ) | ELISA, FC | Mouse IgG |
| PABC-446 | Mouse Anti-CCR5 Recombinant Antibody (clone 4B08) | ELISA | Mouse IgG1, κ |
| HPAB-1659-FY | Human Anti-CCR5 Recombinant Antibody (HPAB-1659-FY) | ELISA | Human IgG |
| HPAB-1660-FY | Mouse Anti-CCR5 Recombinant Antibody (HPAB-1660-FY) | ELISA | Mouse IgG |
| HPAB-1661-FY | Mouse Anti-CCR5 Recombinant Antibody (HPAB-1661-FY) | ELISA | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131CQ-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-0131CQ-S(P)) | ELISA, FC | Mouse scFv |
| PSBC-446 | Mouse Anti-CCR5 Recombinant Antibody (clone 4B08); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1038-FY-F(E) | Human Anti-CCR5 Recombinant Antibody (clone 36F11); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-1578WJ-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (clone ST6/34) | ELISA, WB | Mouse scFv |
| HPAB-1579WJ-S(P) | Human Anti-CCR5 Recombinant Antibody; scFv Fragment (clone ST6) | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1038-FY-S(P) | Human Anti-CCR5 Recombinant Antibody (clone 36F11); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-1659-FY-S(P) | Human Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-1659-FY-S(P)) | ELISA | Human scFv |
| HPAB-1660-FY-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-1660-FY-S(P)) | ELISA | Mouse Fab |
| HPAB-1661-FY-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-1661-FY-S(P)) | ELISA | Mouse Fab |
| HPAB-1662-FY-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-1662-FY-S(P)) | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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