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anti-CCR9 immunotoxin 112509 (IgG)-PE (AGTO-L046E)

This immunotoxin was achieved by conjugating/fusing the Anti-CCR9 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CCR9 expression cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
112509
Molecule Class
IgG2b-PE
Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
Alternative Names
CCR9; chemokine (C-C motif) receptor 9; GPR28; CDw199; GPR-9-6; CC-CKR-9; C-C chemokine receptor type 9; G protein-coupled receptor 28
Entrez Gene ID
10803
UniProt ID
B2R734

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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