Anti-Human CD19 Recombinant Antibody (HD37) (CAT#: TAB-1620CL)
This antibody that can binds to human CD19 is useful in the treatment of diseases and disorders, particularly B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma.
Specific Inquiry
FuncS
Figure 1 A. Inhibition of B cell proliferation by CD19 mAb HD37.
Graded doses of antibody were added to B cells cultivated with anti-μ and BCGF. Mean proliferation ± SE of quadruplicates [three experiments] measured on day 3. B. Comparison of the inhibitory effect of whole (●-●) vs F(ab') (○-○) HD37 mAb. B cells were stimulated with anti μ + RCCF. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
FuncS
Figure 2 Effect of addition of a cross-linking second antibody on CD19-induced inhibition of B cell proliferation.
Cells were cultured with anti-μ + BCGF in the presence of graded doses of HD37 mAb (●-●). Rat anti-mouse κ-Chain mAb was added at 50 μg/ml (■-■). The mean experiments. proliferation ± SE of quadruplicate cultures is shown. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- HD37
- Applications
- FuncS
- Related Disease
- B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H17 | Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-891 | Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
| TAB-1625CL | Anti-Human CD19 Recombinant Antibody (396) | Depletion, ELISA | Humanized antibody |
| TAB-1625CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (396) | Depletion, ELISA | Humanized antibody |
| TAB-431CQ | Anti-Human CD19 Recombinant Antibody | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G076E | Anti-CD19 immunotoxin HD37 (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G076D | Anti-CD19 immunotoxin HD37 (IgG)-DT | Cytotoxicity assay, Function study | |
| AGTO-G076R | Anti-CD19 immunotoxin HD37 (IgG)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G076S | Anti-CD19 immunotoxin HD37 (IgG)-Sap | Cytotoxicity assay, Function study | |
| AGTO-G076P | Anti-CD19 immunotoxin HD37 (IgG)-PAP | Cytotoxicity assay, Function study |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1613CL | Human Anti-CD19 Recombinant Antibody (TAB-1613CL) | Cyt, FC, FuncS, Inhib | Chimeric (mouse/human) IgG1 |
| TAB-1614CL | Human Anti-CD19 Recombinant Antibody (TAB-1614CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1621CL | Anti-Human CD19 Recombinant Antibody (cHD37) | ADCC, FuncS | Chimeric antibody (mouse/human) |
| TAB-1613CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) | Depletion, FuncS | Chimeric (mouse/human) Fab |
| TAB-1621CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1611CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1611CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1620CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HD37) | FuncS | |
| TAB-1622CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1622CL-S(P)) | ELISA, FC, Apop, ADCC, FuncS | Mouse scFv |
| TAB-1623CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1623CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-1624CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (381) | FC, Inhib, ELISA |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1626CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HB12a) | Depletion | Fully human antibody |
| TAB-1616CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1616CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1617CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1617CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1618CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1618CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1619CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1619CL-F(E)) | ELISA, WB | Human Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0264-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0264-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0265-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0265-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0266-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0266-CN) | ELISA, FC | Humanized IgG |
| HPAB-0267-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0267-CN) | ELISA, FC | Humanized IgG |
| HPAB-0268-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0268-CN) | ELISA, FC | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0696LY-F(E) | Mouse Anti-CD19 Recombinant Antibody (clone PGC3D6H10); Fab Fragment | ELISA, WB, FC, IF | Mouse Fab |
| HPAB-0418LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0418LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
| HPAB-0419LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0419LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
| HPAB-0420LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0420LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
| HPAB-0421LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0421LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0986WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0986WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0987WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0987WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0988WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0988WJ-S(P)) | ELISA, FC | Human scFv |
| FAMAB-0071WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone 25C1); scFv Fragment | WB, FC | Human scFv |
| FAMAB-0072WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone BLY3); scFv Fragment | WB, FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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