Recombinant Human monoclonal antibody expressed in CHO binding to Human CD19. MDX-1342 is a fully human monoclonal antibody (HuMAb) with enhanced antibody-dependent cellular cytotoxicity (ADCC) effector function, targeting CD19-membrane receptor which is highly expressed on malignant chronic lymphocytic leukemia (CLL) cells.
Figure 1 Oligosaccharide analysis of MDX-1342 and parental anti-CD19 antibody by capillary electrophoresis with laser induced fluorescence detection; assignment of carbohydrate structures by comparison with glycan standards.
Cardarelli, P. M., Rao-Naik, C., Chen, S., Huang, H., Pham, A., Moldovan-Loomis, M. C., ... & Kuhne, M. R. (2010). A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer immunology, immunotherapy, 59(2), 257.
Figure 2 FACS titration of MDX-1342 binding on human FcRγIIIa transfected CHO-S cells (a), human lymphoma cell lines (b), and FcRγIIIa-Val158-transfected and FcRIIIa-Phe158-transfected CHO cells (c)
Cardarelli, P. M., Rao-Naik, C., Chen, S., Huang, H., Pham, A., Moldovan-Loomis, M. C., ... & Kuhne, M. R. (2010). A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer immunology, immunotherapy, 59(2), 257.
Figure 3 Comparison of ADCC (a) and phagocytosis (b) mediated by MDX-1342 and controls
Cardarelli, P. M., Rao-Naik, C., Chen, S., Huang, H., Pham, A., Moldovan-Loomis, M. C., ... & Kuhne, M. R. (2010). A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer immunology, immunotherapy, 59(2), 257.
Figure 4 Kaplan–Meier plot of the Ramos systemic tumor model treated with MDX-1342 at 0.03, 0.3, 3, and 30 mg/kg
Cardarelli, P. M., Rao-Naik, C., Chen, S., Huang, H., Pham, A., Moldovan-Loomis, M. C., ... & Kuhne, M. R. (2010). A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer immunology, immunotherapy, 59(2), 257.
Figure 5 FACS binding of MDX-1342 to CD40+ human B cells (a) and cynomolgus monkey CD40+ B cells (b), rituximab binding to cynomolgus monkey CD40+ B cells (c), and MDX-1342 binding to CHO cells transfected with cynomolgus monkey CD16 (d)
Cardarelli, P. M., Rao-Naik, C., Chen, S., Huang, H., Pham, A., Moldovan-Loomis, M. C., ... & Kuhne, M. R. (2010). A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer immunology, immunotherapy, 59(2), 257.
Figure 6 In vivo B-cell depletion in cynomolgus monkeys: FACS analysis of cynomolgus CD20+ B cells following a single dose of 1 mg/kg MDX-1342 or parental anti-CD19 mAb (a) and cynomolgus CD40+ B cells following a single dose of 0.1 mg/kg MDX-1342, rituximab, or control IgG1 (b)
Cardarelli, P. M., Rao-Naik, C., Chen, S., Huang, H., Pham, A., Moldovan-Loomis, M. C., ... & Kuhne, M. R. (2010). A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer immunology, immunotherapy, 59(2), 257.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-174 | Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Mouse IgG1, κ |
TAB-1611CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) | Depletion, FuncS | Mouse IgG2a, κ |
TAB-1622CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) | ELISA, FC, Apop, ADCC, FuncS | Mouse IgG |
TAB-1623CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1623CL) | ELISA, FC | Mouse IgG |
TAB-1624CL | Anti-Human CD19 Recombinant Antibody (381) | FC, Inhib, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-891 | Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
TAB-1612CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1612CL-S(P)) | Depletion, FuncS | Humanized scFv |
TAB-1625CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (396) | Depletion, ELISA | Humanized antibody |
TAB-1612CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1612CL-F(E)) | Depletion, FuncS | Humanized Fab |
TAB-1625CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (396) | Depletion, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L047E | anti-CD19 immunotoxin HD37 (scFv)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L047D | anti-CD19 immunotoxin HD37 (scFv)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L047R | anti-CD19 immunotoxin HD37 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L047S | anti-CD19 immunotoxin HD37 (scFv)-Sap | Cytotoxicity assay, Functional assay | |
AGTO-L047P | anti-CD19 immunotoxin HD37 (scFv)-PAP | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1616CL | Human Anti-CD19 Recombinant Antibody (TAB-1616CL) | ELISA, WB | Human IgG |
TAB-1617CL | Human Anti-CD19 Recombinant Antibody (TAB-1617CL) | ELISA, WB | Human IgG |
TAB-1618CL | Human Anti-CD19 Recombinant Antibody (TAB-1618CL) | ELISA, WB | Human IgG |
TAB-1626CL | Anti-Human CD19 Recombinant Antibody (HB12a) | Depletion | Fully human antibody |
TAB-1627CL | Anti-Human CD19 Recombinant Antibody (HB12b) | Depletion | Fully human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1621CL | Anti-Human CD19 Recombinant Antibody (cHD37) | ADCC, FuncS | Chimeric antibody (mouse/human) |
TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
TAB-1614CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1614CL-S(P)) | FuncS | Mouse scFv |
TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
TAB-1621CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0023LY | Humanized Anti-CD19 Recombinant Antibody (HPAB-0023LY) | WB, FC, Cyt | Humanized IgG1 |
HPAB-0036LY | Recombinant Humanized Anti-CD19 Antibody (Hbu12) | WB, IHC | |
HPAB-0418LY | Human Anti-CD19 Recombinant Antibody (HPAB-0418LY) | Cyt, BLI, FC, FuncS, ELISA, WB, RIA | Human IgG1 |
HPAB-0419LY | Human Anti-CD19 Recombinant Antibody (HPAB-0419LY) | ELISA, WB, FC, RIA | Human IgG1 |
HPAB-0420LY | Human Anti-CD19 Recombinant Antibody (HPAB-0420LY) | ELISA, WB, FC, RIA | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0696LY-F(E) | Mouse Anti-CD19 Recombinant Antibody (clone PGC3D6H10); Fab Fragment | ELISA, WB, FC, IF | Mouse Fab |
HPAB-0418LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0418LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
HPAB-0419LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0419LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
HPAB-0420LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0420LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
HPAB-0421LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0421LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP275-YC-S(P) | Human Anti-CD19 Recombinant Antibody (clone 16C4); scFv Fragment | FC, Inhib, ADCC, FuncS | Human scFv |
HPAB-AP276-YC-S(P) | Human Anti-CD19 Recombinant Antibody (clone 16C4-aFuc); scFv Fragment | FC, Inhib, ADCC, FuncS | Human scFv |
HPAB-0986WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0986WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0987WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0987WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0988WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0988WJ-S(P)) | ELISA, FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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