Recombinant Anti-human CD2 Intrabody [Tat] (CAT#: IAB-B074(T))
Recombinant anti-CD2 intrabody in fusion with HIV Tat works within cells that topretransfected with the relevant cell surface antigen CD2, expressed in E. coli cells.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line JURKAT
(Immunofluorescent staining of human cell line JURKAT shows localization to nucleoplasm, plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/2036_G3_1_selected.jpg
(Immunofluorescent staining of human cell line JURKAT shows localization to nucleoplasm, plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/2036_G3_1_selected.jpg
Figure 2 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_8_8.jpg
Figure 3 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_4_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_4_8.jpg
Figure 4 RNA cell line category: Group enriched (HDLM-2, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
Figure 4 RNA cell line category: Group enriched (HDLM-2, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
Specifications
- Immunogen
- human CD2 molecule
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies
Product Property
- Purity
- >95% by HPLC
- Storage
- 4 °C, -20°C if preferred
Target
- Alternative Names
- CD2; CD2 molecule; T11; SRBC; LFA-2; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor
- Gene ID
- 914
- UniProt ID
- P06729
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1136z | Mouse Anti-CD2 Recombinant Antibody (clone 23B6) | ELISA, FC, IF, IHC, IP, FuncS | Mouse IgG2b, κ |
| ZG-0903F | Mouse Anti-CD2 Recombinant Antibody (clone T6.3) | FC | Mouse IgG2a |
| VS3-QX179 | Mouse Anti-CD2 Recombinant Antibody (clone 3F10-7F8-3A1) | IHC | Mouse IgG1 |
| VS3-FY256 | Recombinant Mouse Anti-CD2 Antibody (clone 3F3) | IHC | Mouse IgG |
| VS4-WK80 | Mouse Anti-CD2 Recombinant Antibody (VS4-WK80) | ELISA, IHC | Mouse IgG |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B074(A) | Recombinant Anti-human CD2 Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B074(G) | Recombinant Anti-human CD2 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-104 | Anti-Human CD2 Recombinant Antibody (Siplizumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-110CL | Anti-Human CD2 Recombinant Antibody (BTI-322) | FuncS | Antibody |
Mouse Antibody
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-295CQ | Mouse Anti-CD2 Recombinant Antibody (clone CBL975) | WB, FC, Neut, IHC | Mouse IgG1, κ |
| NEUT-296CQ | Mouse Anti-CD2 Recombinant Antibody (clone RPA-2.10) | WB, Neut, FC, IHC, IHC-Fr | Mouse IgG1, κ |
| NEUT-297CQ | Mouse Anti-CD2 Recombinant Antibody (clone TS1/8) | Neut, FC, CyTOF | Mouse IgG1 |
| NEUT-299CQ | Rat Anti-CD2 Recombinant Antibody (clone 12-15) | Neut, FC, IP | Rat IgG1, κ |
| NEUT-300CQ | Rat Anti-CD2 Recombinant Antibody (clone RM2) | FC, FuncS, Neut | Rat IgG2b, λ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-298CQ | Mouse Anti-CD2 Recombinant Antibody (clone TS218) | Block, FC, IP, WB | Mouse IgG1, κ |
| NEUT-301CQ | Rat Anti-CD2 Recombinant Antibody (clone RM2-5) | FC, IP, Block, Costim | Rat IgG2b, λ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0542 | Hi-Affi™ Rabbit Anti-CD2 Recombinant Antibody (clone DS542AB) | WB, IHC, ICC, IP | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019-LSX-S(P) | Human Anti-CD2 Recombinant Antibody (clone 35.1); scFv Fragment | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019-LSX-F(E) | Human Anti-CD2 Recombinant Antibody (clone 35.1); Fab Fragment | ELISA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-104 | Afuco™ Anti-CD2 ADCC Recombinant Antibody (Siplizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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