Products

Anti-CD20 Immunocytokine, IgG (Rituximab)-RLI (ACFP-SH135)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD20 IgG to RLI. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD20 as well as the biological activity of RLI. Anti-CD20-RLI kept its binding capacity to CD20, CD16 and IL15 receptor and therefore fully retained both antibody effector functions (ADCC and CDC), and the cytokine potential of RLI. In a severe combined immunodeficiency (SCID) mouse model of disseminated residual lymphoma, anti-CD20-RLI was found to induce long-term survival of 90% of mice up to at least 120 days whereas RLI and RTX, alone or in combination, just delayed the disease onset. This immunocytokine was designed for treating leukemias, lymphomas, rheumatoid arthritis, and other autoimmune diseases.      

Specifications
Target
CD20
Molecule Class
L Kappa; IgG2-RLI
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
Rituximab
Related Disease
Leukemias, Lymphomas, Rheumatoid arthritis, and other autoimmune diseases
Cytokines 1
RLI
Cytokines 1 Description
ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
MS4A1; membrane-spanning 4-domains; subfamily A; member 1; B1; S7; Bp35; CD20
Entrez Gene ID
931
UniProt ID
A0A024R507

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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