Anti-Human CD200R1 Recombinant Antibody (DX182) (CAT#: TAB-1708CL)

This antibody specific for the human inhibitory CD200R can modulate its activity in inflammatory and autoimmune disorders.


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  • Published Data
  • Gene Expression
  • Datasheet
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FuncS

Figure 1 shows the effects of anti-human CD200R antibodies DX176, DX177, DX178, DX182 and DX184 in a mast cell degranulation assay.

Figure 1 shows the effects of anti-human CD200R antibodies DX176, DX177, DX178, DX182 and DX184 in a mast cell degranulation assay.

FuncS

Figure 2 shows expression of CD200R on cultured cynomolgus mast cells using DX182 (anti-huCD200R).

Figure 2 shows expression of CD200R on cultured cynomolgus mast cells using DX182 (anti-huCD200R).

Cultured peripheral blood derived cynomolgus mast cells were stained with control antibody, DX49 (isotype control for in vivo study), CD117 (stem cell factor receptor), DX182 (anti-huCD200R) and DX80 (FcεRI).

Inhib

Figure 3 shows DX182 inhibits cultured cynomolgus mast cell FcεR1 induced degranulation.

Figure 3 shows DX182 inhibits cultured cynomolgus mast cell FcεR1 induced degranulation.

Cultured cynomolgus mast cells were incubated with isotype control antibody, DX49 or anti-huCD200R antibody, DX182 and then triggered with an anti-FcεR1 antibody to induce degranulation. In a dose dependent fashion, DX182 inhibited the mast cell degranulation induced by triggering the FcεR1 receptor.

IP

Figure 4 shows cynoCD200RLa is a single polypeptide chain that pairs with Dap 12.

Figure 4 shows cynoCD200RLa is a single polypeptide chain that pairs with Dap 12.

Mouse mast cells transfected with cynomolgus CD200RLa were immunprecipitated with control antibody or DX182. DX182 immunoprecipitated cynomolgus CD200RLa from these transfectants. Western blotting for Dap12 shows that cynomolgus CD200RLa is associated with this signal adaptor protein.

FuncS

Figure 5 shows DX182 induces degranulation of mouse mast cells expressing Cynomolgus CD200RLa.

Figure 5 shows DX182 induces degranulation of mouse mast cells expressing Cynomolgus CD200RLa.

Mouse mast cells transfected with cynomolgus CD200RLa were incubated with DX182 and assayed for mast cell degranulation. DX182 induced a potent mast cell degranulation.


Specifications

  • Immunogen
  • An immunogenic fusion protein comprising the extracellular domain of the human inhibitory receptor CD200R fused to the Fc portion of human IgG1
  • Host Species
  • Rat
  • Specificity
  • Human
  • Clone
  • DX182
  • Applications
  • FuncS, IP, Inhib
  • Related Disease
  • Inflammatory and autoimmune disorders

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay, Immunoprecipitation, Inhibition.

Target

  • Alternative Names
  • CD200R1; CD200 receptor 1; OX2R; MOX2R; CD200R; HCRTR2; cell surface glycoprotein CD200 receptor 1; MOX2 receptor; CD200 cell surface glycoprotein receptor; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4030 Hi-Affi™ Rabbit Anti-CD200R1 Recombinant Antibody (clone SI95DS) ELISA Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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