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Anti-CD22 immunotoxin RFB4 (IgG)-Sap (AGTO-G077S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of B cell lymphoma.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
RFB4
Molecule Class
L kappa; IgG-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
B Cell Lymphoma
Target
Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14
Entrez Gene ID
933
UniProt ID
P20273

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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